{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:55:06Z","timestamp":1792799706085,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"national institute for health and care research","doi-asserted-by":"publisher","award":["RF1AG062496"],"award-info":[{"award-number":["RF1AG062496"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Scientific and Technological Research Council of Turkiye","award":["TUBITAK BIDEB 2214-1059B142300611"],"award-info":[{"award-number":["TUBITAK BIDEB 2214-1059B142300611"]}],"id":[{"id":"https:\/\/ror.org\/04w9kkr77","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Chronic apical periodontitis (CAP) is a persistent inflammatory condition caused by microbial infections in the root canal system, leading to bone loss and tissue damage. In this study, we tested the hypothesis that maresin 1 (MaR1), a specialized proresolving mediator, facilitates inflammatory resolution and promotes bone healing in CAP. We developed a CAP model in mice through pulp exposure. Animals received intracanal administration of either MaR1 or a vehicle. Micro\u2013computed tomography (micro-CT) was used to analyze lesion size and bone volume changes. Inflammatory cell infiltration was assessed in hematoxylin and eosin\u2013stained sections, and microbial diversity was analyzed using next-generation sequencing. The role of regulatory T cells (Tregs) was further explored through diphtheria toxin\u2013induced depletion of Tregs in Foxp3eGFP\/IL17 transgenic mice. All statistical analyses were performed using parametric methods, as confirmed by the Shapiro\u2013Wilk test for data normality. Analysis of variance with Tukey\u2019s post hoc and Bonferroni-corrected\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    tests was applied.\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05 was considered significant. In 2-dimensional analyses, a significant difference was observed between the control and lesion groups, supporting the validity of the experimental model. MaR1 treatment significantly reduced lesion size (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The bone volume\/total volume ratio was significantly higher in the MaR1 group than in the vehicle group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Bone mass was reduced in the lesion group, whereas MaR1 treatment significantly alleviated this loss (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The number of inflammatory cells was significantly lower in the MaR1 group compared to the vehicle group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.05). MaR1 also reduced\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    , a key pathogen in persistent infections. This study highlights MaR1 as a promising treatment for chronic apical periodontitis, showing benefits in resolving inflammation, preserving bone, and reducing\n                    <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                    . Unlike conventional therapies, MaR1 supports immune modulation and tissue repair.\n                  <\/jats:p>","DOI":"10.1177\/00220345251399558","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T04:47:02Z","timestamp":1766033222000},"page":"1163-1173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Maresin 1 Resolves Inflammation and Aids Bone Healing in Periapical Lesions"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-5676","authenticated-orcid":false,"given":"E.","family":"Demir","sequence":"first","affiliation":[{"name":"Ege University School of Dentistry Department of Endodontics, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7546-2048","authenticated-orcid":false,"given":"I.","family":"\u0130lgenli","sequence":"additional","affiliation":[{"name":"Ege University School of Dentistry Department of Endodontics, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-0773","authenticated-orcid":false,"given":"Z.","family":"Guney","sequence":"additional","affiliation":[{"name":"Medipol University School of Dentistry Department of Periodontology, Ankara, Turkey"},{"name":"The ADA Forsyth Institute, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"The ADA Forsyth Institute, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9090-9729","authenticated-orcid":false,"given":"K.","family":"Lauwens","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-0928","authenticated-orcid":false,"given":"N.","family":"Yakar","sequence":"additional","affiliation":[{"name":"The ADA Forsyth Institute, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Alvarez Rivas","sequence":"additional","affiliation":[{"name":"The ADA Forsyth Institute, Cambridge, MA, USA"},{"name":"University at Buffalo School of Dentistry Oral Biology Department, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-5925","authenticated-orcid":false,"given":"O.","family":"Unlu","sequence":"additional","affiliation":[{"name":"Istanbul Atlas University Faculty of Medicine, Department of Medical Microbiology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-9100","authenticated-orcid":false,"given":"A.","family":"Kantarci","sequence":"additional","affiliation":[{"name":"The ADA Forsyth Institute, Cambridge, MA, USA"},{"name":"Harvard University, School of Dental Medicine, Boston, MA, USA"},{"name":"University of Minnesota, School of Dentistry, Developmental and Surgical Sciences, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"crossref","unstructured":"Albuquerque-Souza E et al 2020. Maresin-1 and Resolvin E1 promote regenerative properties of periodontal ligament stem cells under inflammatory conditions. Front Immunol. 11:585530. https:\/\/doi.org\/10.3389\/fimmu.2020.585530","DOI":"10.3389\/fimmu.2020.585530"},{"key":"e_1_3_2_3_1","doi-asserted-by":"crossref","unstructured":"Alvarez C et al 2021. RvE1 Impacts the gingival inflammatory infiltrate by inhibiting the T cell response in experimental periodontitis. Front Immunol. 12:664756. https:\/\/doi.org\/10.3389\/fimmu.2021.664756","DOI":"10.3389\/fimmu.2021.664756"},{"key":"e_1_3_2_4_1","first-page":"1142","article-title":"Development of CD4+ memory T cells in periodontal health and disease","volume":"212","author":"Alvarez Rivas C","year":"2024","unstructured":"Alvarez Rivas C, et al 2024. Development of CD4+ memory T cells in periodontal health and disease. J Immunol. 212(1 Suppl):1142.","journal-title":"J Immunol"},{"key":"e_1_3_2_5_1","doi-asserted-by":"crossref","unstructured":"Artaza L et al 2024. Outcome of nonsurgical root canal treatment of teeth with large apical periodontitis lesions: a retrospective study. J Endod. 50(10):1403\u20131411. https:\/\/doi.org\/10.1016\/j.joen.2024.08.003","DOI":"10.1016\/j.joen.2024.08.003"},{"key":"e_1_3_2_6_1","doi-asserted-by":"crossref","unstructured":"Aubeux D et al 2021. Review of animal models to study pulp inflammation. Front Dent Med. 2:673552. https:\/\/doi.org\/10.3389\/fdmed.2021.673552","DOI":"10.3389\/fdmed.2021.673552"},{"key":"e_1_3_2_7_1","doi-asserted-by":"crossref","unstructured":"Campos K et al 2015. FOXP3 DNA methylation levels as a potential biomarker in the development of periapical lesions. J Endod. 41(2):212\u2013218. https:\/\/doi.org\/10.1016\/j.joen.2014.10.003","DOI":"10.1016\/j.joen.2014.10.003"},{"key":"e_1_3_2_8_1","doi-asserted-by":"crossref","unstructured":"Chiang N Libreros S Norris PC De La Rosa X Serhan CN. 2019. Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. 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