{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:37:35Z","timestamp":1793093855367,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82573176, 82273320, 81991500, 81991502"],"award-info":[{"award-number":["82573176, 82273320, 81991500, 81991502"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020756","name":"west china school of stomatology, sichuan university","doi-asserted-by":"publisher","award":["RCDWJS2023-3"],"award-info":[{"award-number":["RCDWJS2023-3"]}],"id":[{"id":"10.13039\/100020756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Oral diseases, including oral cancer, periodontitis, and oral mucosal disorders, pose major global public health challenges and are driven by complex molecular mechanisms. While recent advances in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have unraveled the heterogeneity of these diseases, integrative analyses remain hindered by severe batch effects, inconsistent metadata annotations, and the fragmentation of public datasets. To address these challenges, we present OralDB (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/compbio.cn\/oraldb\/\">https:\/\/compbio.cn\/oraldb\/<\/jats:ext-link>\n                    ), the first comprehensive, standardized, and interactive multimodal transcriptomic resource dedicated to oral diseases. OralDB integrates 73 high-quality datasets spanning 20 oral diseases and 4 omics types (microarray, RNA-seq, scRNA-seq, ST), covering 2,027 tissue-based samples. The platform applies rigorous processing pipelines, including quality control, dimensionality reduction, clustering, and cell-type annotation, and provides interactive analytical modules for gene expression visualization, differential expression, pathway enrichment, gene correlation, and cell\u2013cell interaction analysis. OralDB enables efficient exploration of molecular and cellular features across disease contexts. We demonstrate the platform\u2019s utility through case studies of\n                    <jats:italic toggle=\"yes\">SERPINE2<\/jats:italic>\n                    -driven epithelial\u2013mesenchymal transition in oral squamous cell carcinoma and fibroblast-derived\n                    <jats:italic toggle=\"yes\">CXCL1<\/jats:italic>\n                    -mediated myeloid cell recruitment in periodontitis. By facilitating mechanistic insights and supporting translational applications, OralDB offers a robust resource to advance precision research and therapeutic development in oral diseases.\n                  <\/jats:p>","DOI":"10.1177\/00220345251410498","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:29:08Z","timestamp":1773224948000},"page":"1350-1358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["OralDB: A Transcriptomic Resource for Mechanistic Exploration in Oral Diseases"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6373-1959","authenticated-orcid":false,"given":"H.","family":"Cui","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy 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Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 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Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 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