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However, the mechanisms underlying this exacerbation remain unclear. In this study, we established a colitis+AP model and demonstrated that colitis exacerbates alveolar bone destruction. The upregulation of genes related to inflammation and neutrophils was also observed in the colitis+AP model compared with the AP-only model. In addition, colitis-induced local neutrophil infiltration was observed in the alveolar bone, which was further amplified by bacterial infection originating from the root canal. To address the exacerbated bone destruction in colitis+AP, we used a novel laser-induced cavitation system to locally deliver the immunosuppressant tacrolimus into the jawbone. This targeted approach effectively suppressed alveolar bone loss in the colitis+AP model. Our findings highlight the importance of the inflammatory interplay between IBD and AP. Systemic inflammation caused by IBD weakens local neutrophil function, leading to increased bone destruction and treatment-resistant AP. Furthermore, laser-activated local administration of tacrolimus significantly ameliorated bone destruction in AP associated with colitis.<\/jats:p>","DOI":"10.1177\/00220345251412776","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:18:12Z","timestamp":1771935492000},"page":"1317-1327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Method to Target Apical Periodontitis Worsened by Inflammatory Bowel Disease"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5850-5737","authenticated-orcid":false,"given":"M.","family":"Nakano","sequence":"first","affiliation":[{"name":"Division of Operative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 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