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While local factors have been extensively investigated, the influence of systemic metabolic disorders\u2014particularly hyperlipidemia\u2014on implant outcomes remains insufficiently understood. Hyperlipidemia is among the most common metabolic diseases globally and is increasingly recognized for its adverse effects on bone metabolism, immune response, and microcirculation. However, its role in osseointegration, which is responsible for peri-implant bone healing and the development of peri-implant diseases, is still controversial and lacks systematic evaluation. Based on our summary of the latest literature, the process of osseointegration can be summarized as angiogenesis-mediated 5-phase osseointegration. The 5 phases refer to 1) hydration\/protein adsorption, 2) platelet-mediated fibrin clot formation, 3) immune cell adhesion, 4) osteogenic\u2013bacterial competitive adhesion, and 5) angiogenesis\u2013osteogenesis coupling. Angiogenesis-mediated 5-phase osseointegration facilitates a dynamic perspective for understanding the physiological processes involved in osseointegration. This review comprehensively summarizes clinical and experimental studies on the relationship between hyperlipidemia and osseointegration. The analysis focuses on peri-implant bone healing and peri-implant disease development from the perspective of angiogenesis-mediated 5-phase osseointegration. To our knowledge, this review creatively integrates both clinical and experimental evidence regarding the impact of hyperlipidemia on peri-implant bone healing and complications.<\/jats:p>","DOI":"10.1177\/00220345261442179","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:12:54Z","timestamp":1780906374000},"page":"972-981","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Hyperlipidemia on Osseointegration and Peri-implant Diseases"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-1801","authenticated-orcid":false,"given":"R.","family":"Mai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China"},{"name":"Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-820X","authenticated-orcid":false,"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; 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