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In addition to these oral findings, pSjD also presents with systemic manifestations such as arthritis, cutaneous vasculitis, and involvement of internal organs. This systematic review and meta-analysis aimed to assess the risk of oral disorders and differences in cariological and periodontal indices in pSjD patients compared with controls. The systematic search was conducted in PubMed, EMBASE, and CENTRAL on November 8, 2024 (PROSPERO: CRD42024608240). Studies meeting the eligibility criteria included adult patients with pSjD. Primary outcomes included the odds ratio (OR) and prevalence of oral disorders as well as the mean difference (MD) and single mean values of dental indices. Meta-analyses were performed using random-effects models to calculate pooled outcome measures and corresponding 95% confidence intervals (CIs). Seventy-five studies were included in the systematic review, with 49 eligible for meta-analysis. The following oral disorders showed increased risk: candidiasis (OR: 10.5; CI: 6.99 to 15.79), dysphagia (OR: 26.78; CI: 20.94 to 34.25), dysgeusia (OR: 17; CI: 4.52 to 63.96), stomatitis (OR: 2.65; CI: 2.17 to 3.23), angular cheilitis (OR: 6.31; CI: 1.94 to 20.53), papillary atrophy (OR: 6.68; CI: 1.12 to 42.16), and fissured tongue (OR: 11.72; CI: 3.42 to 40.18). Patients with pSjD were found to have fewer teeth (MD: \u22122.16; CI: \u22124.27 to \u22120.05) and a higher decayed, missing, filled teeth (MD: 4.72; CI: 3.01 to 6.43) and decayed, missing, filled surfaces (MD: 20.45; CI: 10.16 to 30.74) scores. Furthermore, periodontal parameters showed no significant differences. Patients with pSjD have up to a 30-fold higher risk of developing various oral disorders, emphasizing the need for preventive dental care and early recognition.<\/jats:p>","DOI":"10.1177\/00220345261450057","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:10:24Z","timestamp":1782457824000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Burden of Sj\u00f6gren Disease: A Systematic Review and Meta-analysis"],"prefix":"10.1177","author":[{"given":"\u00c1.","family":"Heizer","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Department of Preclinical Dentistry, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kisgergely","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Department of Prosthodontics, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Sipos","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Qian","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Department of Prosthodontics, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-8198","authenticated-orcid":false,"given":"G.","family":"Varga","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Department of Oral Biology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary"},{"name":"Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6525-2511","authenticated-orcid":false,"given":"K.","family":"M\u00e1rton","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"},{"name":"Department of Preclinical Dentistry, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Aga OO Bolstad AI Lie SA Svanes Fevang BT. 2023. 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