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Here, we present an ASP-repelling mineralization strategy based on a phase-transitioned bovine serum albumin (PTB) nanocoating fabricated via amyloid-like protein self-assembly. The PTB nanocoating confers robust antifouling properties that effectively inhibit ASP adsorption while simultaneously providing exceptional biomineralization activity. Under simulated physiological oral conditions, PTB drives heterogeneous nucleation and crystallization of calcium phosphate, generating a dense, well-integrated remineralized layer for enamel restoration. Both in vitro and in vivo evaluations demonstrate that ASP-coated enamel exhibits markedly attenuated remineralization capacity, whereas PTB treatment reverses this inhibition by efficiently repelling ASP and leveraging its abundant amino acid residues alongside amyloid-like architectures to direct mineral deposition. This work elucidates the interaction between ASP and remineralizing interfaces, providing a conceptually novel and clinically promising avenue to overcome remineralization barriers for caries prevention and enamel restoration.<\/jats:p>","DOI":"10.1177\/00220345261461497","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:05:54Z","timestamp":1784289954000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reversing Enamel Mineralization Inhibition Using Amyloid-like Protein Film"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3722-573X","authenticated-orcid":false,"given":"B.","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi\u2019an, China"},{"name":"Xi\u2019an Key Laboratory of 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