{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:38:03Z","timestamp":1788777483171,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key R&D Program of Shandong Province of China","award":["No. 2025CXPT113"],"award-info":[{"award-number":["No. 2025CXPT113"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82320108004, No. 82270987, and No. 82471030"],"award-info":[{"award-number":["No. 82320108004, No. 82270987, and No. 82471030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Construction Engineering Special Fund of \u201cTaishan Scholars\u201d of Shandong Province","award":["tsqn202211327 and tstp20250510"],"award-info":[{"award-number":["tsqn202211327 and tstp20250510"]}]},{"DOI":"10.13039\/501100012166","name":"national key research and development program of china","doi-asserted-by":"publisher","award":["No.2023YFC2506300 and No. 2023YFC3605600"],"award-info":[{"award-number":["No.2023YFC2506300 and No. 2023YFC3605600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"abstract":"<jats:p>\n                    Aging significantly impairs guided bone regeneration (GBR) by disrupting stem cell recruitment and exacerbating cellular senescence. To address this challenge, we engineered a quercetin and Sr-hydroxyapatite\/poly(lactic-co-glycolic acid) (QSHP) Janus barrier membrane. The asymmetric design featured a dense poly(lactic-co-glycolic acid) layer for epithelial exclusion and a functionalized nanowire layer that enabled controlled codelivery of Sr\n                    <jats:sup>2+<\/jats:sup>\n                    and quercetin. In vitro, the QSHP membrane markedly enhanced the migration and proliferation of bone marrow mesenchymal stem cells while effectively mitigating H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced senescence and restoring osteogenic capacity. In aged rat mandibular defects, the QSHP membrane treatment yielded the highest newly formed bone volume and restored biomechanical properties approaching those of native bone. Histological and immunofluorescence analyses revealed accelerated early osteogenesis, increased recruitment of CD44\n                    <jats:sup>+<\/jats:sup>\n                    stem cells, and concomitant attenuation of cellular senescence. Collectively, the QSHP membrane rejuvenates the senescence-impaired bone regenerative niche, enabling functional bone regeneration and offering a clinically promising strategy for GBR in aged patients.\n                  <\/jats:p>","DOI":"10.1177\/00220345261464526","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:58:29Z","timestamp":1784959109000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Bioactive Janus Barrier Membrane Rejuvenates Bone Regeneration in Aging"],"prefix":"10.1177","author":[{"given":"L.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-5078","authenticated-orcid":false,"given":"B.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Disease &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-5480","authenticated-orcid":false,"given":"S.","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Periodontology &amp; Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &amp; 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