{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:22:02Z","timestamp":1777810922454,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1986,2,1]],"date-time":"1986-02-01T00:00:00Z","timestamp":507600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:p>This study sought to determine whether the lingual ascorbic acid test (LAAT) and measurement of salivary ascorbate refXect plasma and leukocyte ascorbate levels during controlled periods of ascorbic acid depletion and supplementation.<\/jats:p>\n                  <jats:p>Eleven healthy non-smoking men, aged 19-28 years, ate a diet that was repeated every seven days and was adequate in all nutrients except ascorbic acid (AA). This basal diet, which provided less than 5 mg of AA per day, was supplemented with 60 mg of AA per day for two weeks, 0 mg (placebo) per day for four weeks, 600 mg per day for three weeks, and 0 mg per day for four weeks. Oral examinations, the lingual ascorbic acid test, and measurement of salivary, plasma, and leukocyte ascorbate concentrations were conducted throughout the study.<\/jats:p>\n                  <jats:p>Ascorbic acid concentrations in plasma and leukocytes responded rapidly to changes in vitamin C intake. LAAT-derived ascorbate values were unrelated to ascorbic acid intake and plasma and leukocyte ascorbate concentrations. Salivary ascorbate levels approached the lower limits of detection of the assay and remained constant throughout the investigation. Oral hygiene was consistently excellent, and no severe mucosal or periodontal changes were observed. It was concluded that lingual ascorbic acid test values and salivary ascorbate levels are not related to changes in ascorbic acid intake and are not consistent with plasma or leukocyte ascorbate concentrations.<\/jats:p>","DOI":"10.1177\/00220345860650020801","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"131-134","source":"Crossref","is-referenced-by-count":21,"title":["Response of Lingual Ascorbic Acid Test and Salivary Ascorbate Levels to Changes in Ascorbic Acid Intake"],"prefix":"10.1177","volume":"65","author":[{"given":"P.J.","family":"Leggott","sequence":"first","affiliation":[{"name":"School of Dentistry, University of California-San Francisco, San Francisco, California 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.B.","family":"Robertson","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of California-San Francisco, San Francisco, California 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.L.","family":"Rothman","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of California-San Francisco, San Francisco, California 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of California-San Francisco, San Francisco, California 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Jacob","sequence":"additional","affiliation":[{"name":"USDA-ARS, Western Human Nutrition Research Center, San Francisco, California 94129"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(72)90175-6"},{"key":"atypb2","first-page":"114","volume":"38","author":"Cheraskin, E.","year":"1968","journal-title":"I. Reproducibility, Int Z Vitam Erndhrungsforsch"},{"key":"atypb3","first-page":"120","volume":"38","author":"Cheraskin, E.","year":"1968","journal-title":"Int Z Vitam Ern\u00e4hrungsforsch"},{"key":"atypb4","first-page":"254","volume":"38","author":"Cheraskin, E.","year":"1968","journal-title":"Int Z Vitam Ern\u00e4hrungsforsch"},{"key":"atypb5","first-page":"118","volume":"25","author":"Cheraskin, E.","year":"1970","journal-title":"J Oral Med"},{"key":"atypb6","first-page":"31","volume":"34","author":"Cheraskin, E.","year":"1964","journal-title":"Int Z Vitam Erndhrungsforsch"},{"key":"atypb7","volume-title":"Diet and the Periodontal Patient","author":"Clark, J.W.","year":"1970"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220801"},{"key":"atypb9","first-page":"257","volume":"26","author":"Dreizen, S.","year":"1955","journal-title":"Int Z Vitam Ern\u00e4hrungsforsch"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90075-8"},{"key":"atypb11","first-page":"225","volume":"18","author":"Freeman, J.T.","year":"1951","journal-title":"Blood, Urine and Saliva, Gastroenterol"},{"key":"atypb12","first-page":"327","volume":"30","author":"Giza, T.","year":"1960","journal-title":"Int Z Vitam Erndhrungsforsch"},{"key":"atypb13","first-page":"234","volume":"20","author":"Glavind, J.","year":"1948","journal-title":"Int Z Vitam Ern\u00e4hrungsforsch"},{"key":"atypb14","author":"Graves, C.E.","year":"1982","journal-title":"Dent Hygiene"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-1759(83)90058-3","volume":"57","author":"Hauffman, H.T.","year":"1983","journal-title":"J Immunol Meth"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1177\/00220345490280051301"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1972.tb47386.x"},{"key":"atypb18","first-page":"107","volume":"25","author":"King, D.R.","year":"1970","journal-title":"J Oral Med"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1080\/01483918508067061"},{"key":"atypb20","first-page":"91","volume":"16","author":"Little, J.W.","year":"1965","journal-title":"Odontol Rev"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(69)90201-5"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1021\/ba-1982-0200.ch015"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(79)62181-X"},{"key":"atypb25","first-page":"8","volume":"29","author":"Randolph, P.","year":"1974","journal-title":"J Oral Med"},{"key":"atypb26","first-page":"81","volume":"12","author":"Ringsdorf, W.M., Jr.","year":"1978","journal-title":"Quint Int"},{"key":"atypb27","volume-title":"Laboratory Tests for Assessment of Nutritional Status","author":"Sauberlich, H.E.","year":"1974"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(80)90186-6"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.3109\/10731197409118956"},{"key":"atypb31","first-page":"171","volume":"50","author":"Tillotson, J.A.","year":"1980","journal-title":"Int J Vitam Nutr Res"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345860650020801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345860650020801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:01:15Z","timestamp":1777496475000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345860650020801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,2]]}},"alternative-id":["10.1177\/00220345860650020801"],"URL":"https:\/\/doi.org\/10.1177\/00220345860650020801","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}