{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:07:08Z","timestamp":1777810028173,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:p>\n                    Dispersed salivary acini isolated from the rat submandibular gland by enzymatic digestion were used to study the effects of a-receptor stimulation on transmembrane transport of\n                    <jats:sup>36<\/jats:sup>\n                    Cl. In the absence of secretagogue, the tracer accumulated in the cells in a time-dependent manner until a steady-state content of 6.8 \u00b1 0.1 nmol\/mg protein was attained after 3-5 min of incubation. Epinephrine (1 \u03bcmol\/L) alone did not modify\n                    <jats:sup>36<\/jats:sup>\n                    Cl accumulation but in the presence of the \u03b2-receptor blocker propranolol (1 \u03bcmol\/L) caused a significant (21%) reduction in the isotope content of the cells to 5.2 \u00b1 0.1 nmol\/mg protein. In acini pre-loaded with\n                    <jats:sup>36<\/jats:sup>\n                    Cl for 12 min, 1 \u03bcmol\/L epinephrine caused a rapid but transient net efflux of tracer, but the isotope content subsequently increased to pre-stimulation levels. In the presence of propranolol, however, the efflux of\n                    <jats:sup>36<\/jats:sup>\n                    Cl induced by epinephrine was larger and more sustained and was partially inhibited by the K-channel blocker quinidine (1 mmol\/L) and significantly by the absence of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    in the incubation medium. The a-agonist phenylephrine (10 \u03bcmol\/L) also significantly reduced the steady-state\n                    <jats:sup>36<\/jats:sup>\n                    Cl content of tracer-pre-loaded cells. By contrast, exposure of the acini to epinephrine in the presence of the a-receptor blocker phentolamine, or the \u03b2-agonist isoproterenol, increased the tracer content of the cells, whether the drugs were added at time zero or to tracer-pre-loaded cells. The results indicate that stimulation of a-receptors in salivary acinar cells causes a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent efflux of Cl which seems to be functionally linked to K release. These effects are similar to those observed following stimulation of cholinergic receptors. The lack of effect of \u03b2-receptor stimulation on Cl efflux suggests that this response is not regulated by a cAMP-mediated pathway in salivary cells. The extent of stimulation-induced Cl efflux is likely to be relevant in terms of the amount of saliva secreted upon stimulation.\n                  <\/jats:p>","DOI":"10.1177\/00220345880670030701","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"561-564","source":"Crossref","is-referenced-by-count":9,"title":["Effect of a-Receptor Stimulation on Cl Transport by Rat Submandibular Acini"],"prefix":"10.1177","volume":"67","author":[{"given":"J.R.","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00589260"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582944"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00707943"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583281"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582641"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(87)90103-8"},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0022-3565(25)30605-1","volume":"198","author":"Martinez, J.R.","year":"1976","journal-title":"I. Induction by Catecholamines, J Pharmacol Exp Ther"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0022-3565(25)30267-3","volume":"194","author":"Martinez, J.R.","year":"1975","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015501"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/00220345840630090101"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660080101"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1986.251.2.C175"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.48.030186.000451"},{"key":"atypb15","first-page":"C90","volume":"238","author":"Quissell, D.O.","year":"1980","journal-title":"I. Potassium Release, Am J Physiol"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01925789"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1979.57"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670030701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670030701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:58:48Z","timestamp":1777496328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345880670030701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,3]]}},"alternative-id":["10.1177\/00220345880670030701"],"URL":"https:\/\/doi.org\/10.1177\/00220345880670030701","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}