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The majority of the analyses for teeth obtained from the O.I. patients were biochemically abnormal (55 out of 59). Specifically, there was a significant increase in the acidic amino acids, with a corresponding decrease in the basic amino acids. A small group of patients showed double peaks in the histidine, hydroxylysine, and lysine areas of the chromatograms. These results emphasize that despite the fact that the teeth of O.I. patients may appear to be clinically normal, all but four of the teeth examined had abnormal dentin collagen.<\/jats:p>","DOI":"10.1177\/00220345880670080701","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1097-1102","source":"Crossref","is-referenced-by-count":4,"title":["Abnormal Amino Acid Analyses Obtained from Osteogenesis Imperfecta Dentin"],"prefix":"10.1177","volume":"67","author":[{"given":"J.P.","family":"Gage","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, University of Queensland Dental School, Turbot Street, Brisbane, Queensland 4000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.O.","family":"Francis","sequence":"additional","affiliation":[{"name":"Nuffield Orthop\u0153dic Centre, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Nuffield Orthop\u0153dic Centre, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,8,1]]},"reference":[{"key":"atypb1","first-page":"3838","volume":"79","author":"Barsh, G.S.","year":"1982","journal-title":"A"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.004521"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-516304-0.50009-X"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320170206"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110815"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62369-5"},{"key":"atypb7","unstructured":"Eastoe, J.E. and Leach, A.A. 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