{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:41:38Z","timestamp":1760888498306,"version":"3.34.0"},"reference-count":7,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p> Roots of extracted human molars were treated for both 10 and 30 min with a saturated solution of dicalcium phosphate dihydrate (DCPD) of pH 2.4 and subsequently with a 5.3 mmol.L<jats:sup> -1<\/jats:sup> solution of sodium fluoride of pH 7.0. The objective of these combined treatments was to convert the highly-soluble root mineral into the less-soluble fluoridated hydroxylapatite, with DCPD as an intermediate, to improve caries resistance. The mineral content of the surface layer was not affected in a significant way. <\/jats:p><jats:p> Roots treated in this way were subjected to 50 mmol.L<jats:sup>-1<\/jats:sup> acetate buffer solutions of pH 5.5 and with pI<jats:sub>OHA<\/jats:sub>-values of 112, 116, and 122. The proportional reduction of the rate of demineralization (V<jats:sub>dem<\/jats:sub>) of similarly treated roots subjected to buffer solutions of pI<jats:sub>OHA<\/jats:sub> 112 and 116 appeared to be equal initially. Since fluoridated hydroxylapatite is insoluble under these conditions, these findings are in agreement with expectations. The reduction of V<jats:sub>dem<\/jats:sub> amounted to about 45 and 70% for roots treated for 10 and 30 min, respectively. <\/jats:p><jats:p> When roots were treated for 10 and 30 min and then exposed to buffer solutions with a pI<jats:sub>OHA<\/jats:sub> 122, reductions of V<jats:sub>dem<\/jats:sub> of about 30 and 55%, respectively, were found. <\/jats:p><jats:p> Conversion of the root mineral into fluoridated hydroxylapatite can eliminate, in principle, the existing difference in caries susceptibility of the root and of the dental enamel. <\/jats:p>","DOI":"10.1177\/00220345880670100101","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T02:14:56Z","timestamp":1290996896000},"page":"1254-1256","source":"Crossref","is-referenced-by-count":15,"title":["Improvement of the Caries Resistance of Human Dental Roots by a Two-step Conversion of the Root Mineral into Fluoridated Hydroxylapatite"],"prefix":"10.1177","volume":"67","author":[{"given":"P.M.M.","family":"Hoppenbrouwers","sequence":"first","affiliation":[{"name":"Dental School, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands"}]},{"given":"E.","family":"Groenendijk","sequence":"additional","affiliation":[{"name":"Dental School, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands"}]},{"given":"N.","family":"Ramlochan Tewarie","sequence":"additional","affiliation":[{"name":"Dental School, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands"}]},{"given":"F.C.M.","family":"Driessens","sequence":"additional","affiliation":[{"name":"Dental School, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands"}]}],"member":"179","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345730520061001"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345750540013901"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/00220345800590081501"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/00220345850640021401"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650071101"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(87)90085-9"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660081701"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670100101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670100101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:26:18Z","timestamp":1738041978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345880670100101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1177\/00220345880670100101"],"URL":"https:\/\/doi.org\/10.1177\/00220345880670100101","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"type":"print","value":"0022-0345"},{"type":"electronic","value":"1544-0591"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}