{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:30:16Z","timestamp":1777811416061,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p>Recent evidence has suggested that the cariostatic effects of topical fluoride (F) are related to the presence of low concentrations of ionic F in the oral environment. The purpose of this study was to compare the retention of F in the oral environment over 24-hour periods after the use of a F dentifrice or a F rinse.<\/jats:p>\n                  <jats:p>Groups of ten consenting adult subjects (age 18-52 years) brushed and\/or rinsed (B\/R) in a standardized manner twice per day in the morning (AM) and before bed (PM) with either a placebo dentifrice (8 ppm F), NaF dentifrice (1100 ppm F), or NaF rinse (225 ppm F). Experiments were performed with placebo dentifrice only (PD); F dentifrice only (FD); F dentifizce followed by F rinse (FD\/FR); placebo dentifrice followed by F rinse (PD\/FR); and F rinse followed by placebo dentifrice (FR\/PD). Unstimulated whole saliva samples were collected at baseline and then at 0, 15, 30, and 45 min, 1, 2, and 8 hr after B\/R in the AM, after B\/R in the PM and upon rising the following morning. Salivary flow rate and F were determined for each sampling interval.<\/jats:p>\n                  <jats:p>The results of this study suggest that: (1) F rinse may be a more effective way of delivering topical F than F dentifrice; (2) based on F retention, the combination of FD\/FR was not more effective than FR only (PD\/FR); (3) older individuals with gingival recession retained higher F levels; and (4) bedtime F application resulted in longer F retention than did daytime application, which may have important implications for enamel remineralization.<\/jats:p>","DOI":"10.1177\/00220345880670100201","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1257-1262","source":"Crossref","is-referenced-by-count":60,"title":["Comparison of Fluoride Concentrations in Unstimulated whole Saliva Following the Use of a Fluoride Dentifrice and a Fluoride Rinse"],"prefix":"10.1177","volume":"67","author":[{"given":"D.T.","family":"Zero","sequence":"first","affiliation":[{"name":"Eastman Dental Center, 625 Elmwood Avenue, Rochester, New York 14620"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fu","sequence":"additional","affiliation":[{"name":"Eastman Dental Center, 625 Elmwood Avenue, Rochester, New York 14620"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Espeland","sequence":"additional","affiliation":[{"name":"Center for Prevention Research and Biometry, Bowman-Gray School of Medicine, 300 S. Hathorne Road, Winston-Salem, North Carolina 27103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.B.","family":"Featherstone","sequence":"additional","affiliation":[{"name":"Eastman Dental Center, 625 Elmwood Avenue, Rochester, New York 14620"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(68)90141-6"},{"key":"atypb2","unstructured":"Arends, J. and Gelhard, T. (1983): In vivo Remineralization of Human Enamel. In: Demineralization and Remineralization of the Teeth, S.A. Leach and W.M. Edgar, Eds. Oxford: IRL Press , pp. 1-16."},{"key":"atypb3","first-page":"245","author":"Arends, J.","year":"1984","journal-title":"Int. Congr. Zurich"},{"key":"atypb4","first-page":"192","volume":"21","author":"Barkvoll, P.","year":"1987","journal-title":"Caries Res"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1159\/000261126"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/00220345760550012001"},{"key":"atypb7","first-page":"1346","volume":"61","author":"Brunelle, J.A.","year":"1982","journal-title":"J Dent Res"},{"key":"atypb8","first-page":"1","volume":"87","author":"Bruun, C.","year":"1979","journal-title":"Scand J Dent Res"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1982.tb01335.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1159\/000260684"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90067-9"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1982.0401"},{"key":"atypb13","unstructured":"Ekstrand, J.; Lagerlof, F.; and Oliveby, A. (1986): Some Aspects of the Kinetics of Fluoride in Saliva . In: Factors Relating to Demineralization and Remineralization of the Teeth, S.A. Leach, Ed. Oxford: IRL Press, pp. 91-98."},{"key":"atypb14","unstructured":"Featherstone, J.D.B.; O'Reilly, M.M.; Shariati, M.; and Brugler, S. (1986): Enhancement of Remineralization in vitro and in vivo. In: Factors Relating to Demineralization and Remineralization of the Teeth, S.A. Leach, Ed. 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(1983): Fluorides in Preventive Dentistry, Chicago: Quintessence Publ. Co., pp. 215-241."},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1177\/00220345740530020901"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1159\/000260712"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(87)90293-9"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1159\/000261004"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(77)90122-4"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1177\/00220345560350010301"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1159\/000260512"},{"key":"atypb35","unstructured":"Stookey, G.K. (1985): Are all Fluoride Dentifrices the Same? In: Clinical Uses of Fluorides, S.H.Y. Wei, Ed. 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