{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:53:50Z","timestamp":1780491230533,"version":"3.54.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p>\n                    Patients with the salivary component of Sj\u00f6gren's syndrome (SS) develop chronic xerostomia, which causes oral symptoms and functional impairment in approximate proportion to its severity. The purpose of this double-blind study was to determine whether an electrical stimulus applied to the tongue and hard palate by a battery-operated device (SAL II, Biosonics, Inc.) could stimulate salivary flow in subjects with generally severe SS. Twenty-nine patients with the salivary component of SS (diagnosed as the presence of focal chronic sialadenitis in a labial salivary gland biopsy specimen with a focus score of &gt; 1 focus\/4 mm\n                    <jats:sup>2<\/jats:sup>\n                    ) were randomly assigned active or placebo devices, which they used for three minutes, three times a day for four weeks. Whole saliva flow rates were measured at weeks 0, 2, and 4 by collection of whole saliva both before and after stimulation with the device. Twenty-four subjects completed the study. The change in mean post-stimulation flow rate from week 0 to week 4 was greater for the 13 subjects using an active device (0.08 \u00b1 S.D. 0.08 gl2 min, to 0.24 \u00b1 0.33 gl2 min) than for the 11 subjects using a placebo device (0.11 \u00b1 0.15 gl2 min, to 0.08 \u00b1 0.18 gl2 min) (p = 0.04). However, the magnitude of the mean difference was small, because three subjects using active devices responded and others did not. Only five subjects, all using active devices, reported a subjective increase in the amount of their saliva. The results of this study indicate that some SS patients with residual salivary flow show a significant response to electrical stimulation, but others with low or absent whole saliva flow rates do not respond.\n                  <\/jats:p>","DOI":"10.1177\/00220345880670101701","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1334-1337","source":"Crossref","is-referenced-by-count":49,"title":["Electrical Stimulation of Salivary Flow in Patients with Sj\u00f6gren's Syndrome"],"prefix":"10.1177","volume":"67","author":[{"given":"M.","family":"Steller","sequence":"first","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of California at San Francisco, San Francisco, California 94143-0512"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of California at San Francisco, San Francisco, California 94143-0512"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of California at San Francisco, San Francisco, California 94143-0512"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270205"},{"key":"atypb2","first-page":"36","volume":"61","author":"Daniels, T.E.","year":"1986","journal-title":"Scand J Rheumatol (Supp)"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(75)90108-5"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660022101"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(69)90182-4"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90369-5"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1985.0384"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660020201"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870315)59:6<1123::AID-CNCR2820590614>3.0.CO;2-X"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90417-4"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.3.282"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(86)90219-3"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670101701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670101701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:02:47Z","timestamp":1777496567000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345880670101701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1177\/00220345880670101701"],"URL":"https:\/\/doi.org\/10.1177\/00220345880670101701","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}