{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:31:04Z","timestamp":1777811464672,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:p>We evaluated the potential of a pyrophosphate-fluoride solution to affect the remineralizing-demineralizing equilibrium, i.e., caries-inhibitingl-promoting effects on enamel in vivo. Fifteen subjects carried dentin blocks and enamel thin sections with artificial caries lesions in removable partial dentures for periods of two weeks, during which time they rinsed twice daily in a double-blind, randomized cross-over design with solutions containing (a) 90 ppm F, (b) 90 ppm F and 1% pyrophosphate, or (c) no active agents (placebo). A severe cariogenic challenge provided to the lesions by plaque under a stainless steel mesh cover resulted in the placebo-treated lesions losing 70.2% \u00b1 72.1% mineral. The pyrophosphate rinse with fluoride held the mineral loss to only 28.1 \u00b1 52.8%, while the fluoride rinse without pyrophosphate held the loss to 24.2 \u00b1 50.1%. The differences between the fluoride and placebo results were significant (p &lt; 0.01), but the difference between the two fluoride groups was not.<\/jats:p>\n                  <jats:p>A large amount of fluoride was deposited in the dentin lesions. In the surface layer, the concentration was increased from 1000 ppm F to more than 2300 ppm F by both fluoride treatments. The concentration of fluoride in both groups of fluoride-treated lesions further increased to more than 3500 ppm F in the approximate center of the lesion before declining in deeper layers toward the level found in the placebo-treated group. The findings from both mineral change and fluoride uptake phases of this study show that in the presence of 90 ppm F, 1% pyrophosphate did not promote demineralization of artificial caries lesions.<\/jats:p>","DOI":"10.1177\/00220345880670120401","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1461-1465","source":"Crossref","is-referenced-by-count":18,"title":["The Effects of 1% Pyrophosphate and 0.02% Sodium Fluoride on Artificial Caries Lesions in vivo"],"prefix":"10.1177","volume":"67","author":[{"given":"J.R.","family":"Mellberg","sequence":"first","affiliation":[{"name":"Colgate-Palmolive Co., Research Center, 909 River Road, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.D.","family":"Petrou","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Co., Research Center, 909 River Road, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Deutchman","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Co., Research Center, 909 River Road, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Grote","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Co., Research Center, 909 River Road, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650010201"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650021701"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1159\/000260936"},{"key":"atypb4","first-page":"108","volume":"66","author":"Essig, M.E.","year":"1987","journal-title":"J Dent Res"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1975.0063"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/00220345720510021701"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/212901a0"},{"key":"atypb8","first-page":"S242","volume":"8","author":"Gaffar, A.","year":"1987","journal-title":"Compend Cont Ed Dent Suppl"},{"key":"atypb9","unstructured":"Jenkins, G.N. (1978): The Physiology and Biochemistry of the Mouth, 4th ed. Oxford: Alden Press, p. 59."},{"key":"atypb10","first-page":"46","volume":"10","author":"Kinoshita, S.","year":"1966","journal-title":"Helv Odont Acta"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/00220345850640020301"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.1986.tb00380.x"},{"key":"atypb13","first-page":"39","volume":"1","author":"Mellberg, J.R.","year":"1988","journal-title":"Am J Dent"},{"key":"atypb14","first-page":"85","volume":"1","author":"Mellberg, J.R.","year":"1988","journal-title":"Am J Dent"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650080701"},{"key":"atypb16","first-page":"S267","volume":"8","author":"Mellberg, J.R.","year":"1987","journal-title":"Compend Cont Ed Dent Suppl"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650080801"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1177\/00220345820610120201"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1159\/000260838"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/00220345880670120401","volume":"67","author":"Mellberg, J.R.","year":"1988","journal-title":"J Dent Res"},{"key":"atypb21","first-page":"193","volume":"1","author":"Mitropoulos, C.M.","year":"1984","journal-title":"Community Dent Oral Epidemiol"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1159\/000260118"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1159\/000260945"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1973.0618"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/BF02547230"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1159\/000261097"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660110801"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1177\/00220345860650080901","volume":"65","author":"Ten Cate, J.M.","year":"1986","journal-title":"J Dent Res"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1159\/000260599"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670120401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345880670120401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:02:54Z","timestamp":1777496574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345880670120401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["10.1177\/00220345880670120401"],"URL":"https:\/\/doi.org\/10.1177\/00220345880670120401","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}