{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:19:02Z","timestamp":1777810742819,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p>The histopathology of active and arrested human root caries was examined in extracted teeth by different optical methods. Significant differences were observed between the mechanisms operating on the various dental structures. Three different patterns of initial cementum and dentin lesions could be distinguished, depending on the severity of the cariogenic attack, the degree of sclerosis of the peripheral dentin, and the presence of calculus. Advanced lesions were characterized by various patterns of demineralization. In particular, a massive lateral spread of bacteria into intertubular dentin was observed. Consequently, unaffected dentinal areas became continuously undermined. In arrested lesions, either a partial or complete mineralization of the intertubular dentin was apparent. Dentinal tubules were sclerosed passively by re- or precipitation of Ca and P04 ions. In contrast, tubules filled with ghosts of bacteria appeared mineralized by fine-granular crystals. Our observations indicate that both the arrestment and the remineralization of active lesions depend on (1) the degree of active sclerosis of dentinal tubules in areas underlying the lesion, (2) the degree of the bacterial infection of the dentin, (3) the degree of progression of the lesions, and (4) the location of the lesions at the various root surfaces. It is suggested that remineralization of active lesions can occur. This supports the concept of non-invasive treatment of root caries lesions without cavitation.<\/jats:p>","DOI":"10.1177\/00220345900690051601","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1195-1204","source":"Crossref","is-referenced-by-count":18,"title":["Histopathology of Root Surface Caries"],"prefix":"10.1177","volume":"69","author":[{"given":"P.","family":"Sch\u00fcpbach","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology and General Immunology, Dental Institute, University of Zurich, Plattenstrasse 11, CH-8028 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Guggenheim","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology and General Immunology, Dental Institute, University of Zurich, Plattenstrasse 11, CH-8028 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Periodontology and Preventive Dentistry, Dental Institute, University of Zurich, Plattenstrasse 11, CH-8028 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.8.493"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2164-0947.1951.tb01007.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.1986.tb00382.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1159\/000260400"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02066.x"},{"key":"atypb6","unstructured":"Fejerskov, O. and Nyvad, B. (1986): Pathology and Treatment of Dental Caries in the Aging Individual. In: Geriatric Dentistry , P. Holm-Pedersen and H. L\u00f6e, Eds. Copenhagen: Munksgaard, pp. 238-262."},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1159\/000261180"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1159\/000260479"},{"key":"atypb9","first-page":"437","volume":"82","author":"Furseth, R.","year":"1974","journal-title":"Scand J Dent Res"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(68)90075-7"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.3109\/00016357009032037"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01503.x"},{"key":"atypb13","unstructured":"Jones, S.J. and Boyde, A. (1987): Dentine Mineralization, Demineralization and Microhardness: Recent Studies Using Scanning Microscopies. In: Dentine and Dentine Reactions in the Oral Cavity, A. Thylstrup , S.A. Leach, and V. Qvist, Eds. Oxford: IRL Press, pp. 33-85."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1973.44.3.158"},{"key":"atypb15","first-page":"137A","volume":"32","author":"Karnovsky, M.J.","year":"1965","journal-title":"J Cell Biol"},{"key":"atypb16","first-page":"339","volume":"6","author":"Kostlan, J.","year":"1963","journal-title":"Bull Group Int Rech Sci Stomatol"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1159\/000259847"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4803312"},{"key":"atypb19","first-page":"187","volume":"112","author":"Miller, W.A.","year":"1962","journal-title":"Br Dent J"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00877.x"},{"key":"atypb21","first-page":"598","volume":"39","author":"Nalbandian, J.","year":"1960","journal-title":"Electron, and X-ray Microscopy, J Dent Res"},{"key":"atypb22","first-page":"312","volume":"32","author":"Nyvad, B.","year":"1982","journal-title":"Int Dent J"},{"key":"atypb23","unstructured":"Nyvad, B. and Fejerskov, O. (1987): Active and Inactive Root Surface Caries-Structural Entities? In: Dentine and Dentine Reactions in the Oral Cavity , A. Thylstrup, S.A. Leach, and V. Qvist, Eds. Oxford: IRL Press, pp. 165-179."},{"key":"atypb24","first-page":"347","volume":"29","author":"Parikh, S.R.","year":"1963","journal-title":"N Y St Dent J"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1177\/00220345650440064601"},{"key":"atypb26","first-page":"111","volume":"83","author":"Schroeder, H.E.","year":"1980","journal-title":"Micros Acta"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb00753.x"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1159\/000261258"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.3109\/00016356509007523"},{"key":"atypb30","unstructured":"Silverstone, L.M. (1974): Structure of Carious Enamel, Including the Early Lesion. In: Oral Science Reviews. 3: Dental Enamel, A.H. Melcher and G.A. Zarb, Eds. Copenhagen : Munksgaard, pp. 100-160."},{"key":"atypb31","first-page":"185","volume":"4","author":"Silverstone, L.M.","year":"1985","journal-title":"Gerodontics"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1159\/000260163"},{"key":"atypb33","unstructured":"Thylstrup, A.; Featherstone, J.D.B.; and Fredebo, L. (1983): Surface Morphology and Dynamics of Early Enamel Caries Development. In: Demineralisation and Remineralisation of the Teeth, S.A. Leach and W.M. Edgar, Eds. Oxford: IRL Press, pp. 165-184."},{"key":"atypb34","unstructured":"Thylstrup, A. and Fejerskov, O. (1986): Pathology of Dental Caries. In: Textbook of Cariology, A. Thylstrup and O. Fejerskov, Eds. Copenhagen : Munksgaard, pp. 204-234."},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(64)90063-9"},{"key":"atypb36","unstructured":"Wefel, J.S.; Clarkson, B.H.; and Heilman, J.R. (1987): Histology of Root Surface Caries. In: Dentine and Dentine Reactions in the Oral Cavity, A. 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