{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:49:18Z","timestamp":1783021758365,"version":"3.54.6"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1990,6,1]],"date-time":"1990-06-01T00:00:00Z","timestamp":644198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:p>We studied the fibrinolytic activities of the following subfractions of unstimulated human whole saliva on plasminogen-rich fibrin plates: (1) submandibular saliva, (2) parotid saliva, and (3) smears of buccal epithelial cells from ten healthy males. A cell-bound plasminogen activator could be demonstrated in the sediments of all three subfractions of whole saliva. The incorporation of antibodies (goat IgG) against human two-chain tissue-type plasminogen activator (t-PA) could quench the assessed fibrinolytic activities, whereas additional experiments suggested the absence of urokinase-like and F XII-dependent activators of fibrinolysis. The determinations in growth medium from buccal-epithelial cell culture of t-PA antigen by means of enzyme-linked immunosorbent assay showed the presence of t-PA.<\/jats:p>\n                  <jats:p>These clinical and experimental findings suggest that buccal-epithelial cells produce t-PA, while the activity of t-PA in parotid and submandibular saliva is very low.<\/jats:p>","DOI":"10.1177\/00220345900690061201","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1283-1286","source":"Crossref","is-referenced-by-count":18,"title":["The Possible Role of Oral Epithelial Cells in Tissue-type Plasminogen Activator-related Fibrinolysis in Human Saliva"],"prefix":"10.1177","volume":"69","author":[{"given":"S.","family":"Sindet-Pedersen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, \u00c5rhus University Hospital, N\u00f8rrebrogade, DK-8000 \u00c5rhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gram","sequence":"additional","affiliation":[{"name":"Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital, \u00d8stergade, DK-6700 Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital, \u00d8stergade, DK-6700 Esbjerg, 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