{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:06:45Z","timestamp":1789060005494,"version":"build-2803163510"},"reference-count":100,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:p>\n                    The chemical and crystallographic events associated with the caries process can be described based on the results from the following studies: (a) effects of carbonate, magnesium, fluoride, and strontium on the physicochemical properties\u2014lattice parameters, crystallinity (crystal size and strain); dissolution properties of synthetic apatites; (b) factors influencing the in vitro formation and transformation of DCPD, OCP, AP (Ca-deficient apatites), FAP, \u03b2-TCMP (Mg-substituted), and CaF\n                    <jats:sub>2<\/jats:sub>\n                    ; and (c) studies on properties (crystallinity, composition, chemical, and thermal stabilities) of enamel, dentin, and bone.\n                  <\/jats:p>\n                  <jats:p>\n                    The dissolution of CO\n                    <jats:sub>3<\/jats:sub>\n                    -rich\/Mg-rich\/F-poor dental apatite crystals and re-precipitation of CO\n                    <jats:sub>3<\/jats:sub>\n                    -poor\/Mg-poor\/F-rich apatite in the presence of F\n                    <jats:sup>-<\/jats:sup>\n                    ions in solution contribute to a more acid-resistant surface layer of the caries lesion. Fluoride promotes the formation of less Ca-deficient and more stable apatite crystals. The presence of Ca, P, and F in solution inhibits dissolution of apatite more than does the presence of F alone. Low levels of F in solution promote the formation of (F, OH)-apatite, even under very acid conditions; an increase in F levels causes the formation of CaF\n                    <jats:sub>2<\/jats:sub>\n                    at the expense of DCPD or apatite, especially in acid conditions. F in apatite and\/or in solution suppresses extensive dissolution of dental apatite and enhances the formation of (F, OH)-apatite crystals which are more resistant against acid-dissolution than are F-free apatite crystals.\n                  <\/jats:p>","DOI":"10.1177\/00220345900690s113","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T01:54:29Z","timestamp":1448416469000},"page":"567-574","source":"Crossref","is-referenced-by-count":73,"title":["Chemical and Crystallographic Events in the Caries Process"],"prefix":"10.1177","volume":"69","author":[{"given":"R.Z.","family":"Legeros","sequence":"first","affiliation":[{"name":"New York University College of Dentistry, 345 East 24th Street, New York, New York 10010"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1990,2,1]]},"reference":[{"key":"bibr1-00220345900690S113","doi-asserted-by":"publisher","DOI":"10.1177\/00220345660450041201"},{"key":"bibr2-00220345900690S113","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68574-3_17"},{"key":"bibr3-00220345900690S113","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650010201"},{"key":"bibr4-00220345900690S113","doi-asserted-by":"publisher","DOI":"10.1007\/BF02546227"},{"key":"bibr5-00220345900690S113","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19811000103"},{"key":"bibr6-00220345900690S113","unstructured":"BAUD C.A., and VERY J.M. 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