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This paper reviews clinical data on water fluoridation, the topical administration of fluorides, and fluoride supplements in the light of more recent understanding of the disease dental caries. Due to reduced functional usage, erupting teeth tend to accumulate plaque which has cariogenic potential. For this reason, the period from tooth emergence to the establishment of interproximal contact and full occlusion is the most critical for caries initiation. Analyses of clinical data indicate that maximum protection against caries is obtained when teeth erupt into an environment with low concentrations of ionic fluoride. The similarity in caries reductions obtained in water fluoridation studies and long-term studies with topically administered fluoride regimens, including fluoride-containing dentifrices, indicates that the pre-eruptive effect of fluoride is of borderline significance relative to the more significant post-eruptive effect. Water fluoridation and topical fluoride programs are thus important measures for the control of caries at the community level. For the individual, topical application of fluoride is seen as an integral part of caries treatment aimed at arresting progressive caries. Fluoride application is thus considered a supportive therapy, in conjunction with cariogenic plaque control. Daily use of fluoridated dentifrices from tooth eruption is more efficacious than daily use of fluoride supplements from birth.<\/jats:p>","DOI":"10.1177\/00220345900690s144","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T01:54:29Z","timestamp":1448416469000},"page":"742-750","source":"Crossref","is-referenced-by-count":54,"title":["Clinical Evidence of the Role of Pre-eruptive Fluoride in Caries Prevention"],"prefix":"10.1177","volume":"69","author":[{"given":"A.","family":"Thylstrup","sequence":"first","affiliation":[{"name":"Department of Cariology and Endodontics, Royal Dental College, N\u00f8orre All\u00e9 20, DK-2200 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,2,1]]},"reference":[{"key":"bibr1-00220345900690S144","first-page":"233","volume":"55","author":"AINSWORTH N.J.","year":"1933","journal-title":"Br Dent 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