{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:22:08Z","timestamp":1783074128219,"version":"3.54.6"},"reference-count":30,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:p>A longitudinal study of children from ages 7 to 18 showed that, if enamel lesions were included, the overall number was the same in fluoridated and non-fluoridated areas. However, a significant reducing effect of pre-emptive fluoride could be seen in the number of dentinal lesions in a fluoridated area, provided that fluoride was also consumed post-eruptively for a considerable period of time. A precise estimation of both pre- and post-eruptive effects was obtained when teeth were classified according to their eruption time as related to the onset of water fluoridation. About 66% of the greatest reduction in pit and fissure caries came from pre-emptive fluoride, while in smooth surfaces, this effect was reduced to 25%. In approximal surfaces, the reduction was due half to pre- and half to post-eruptive fluoride. Post-eruptive fluoride became more important with decreasing severity of caries attack. Thus, assuming a continuing decline in dental caries, the majority of such populations will benefit most from the use of topical fluorides. However, in high-risk groups, supplementation of pre-emptive fluoride can still be of major importance.<\/jats:p>","DOI":"10.1177\/00220345900690s145","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T01:54:29Z","timestamp":1448416469000},"page":"751-755","source":"Crossref","is-referenced-by-count":85,"title":["Fluoride in Caries Prevention: Is the Effect Pre- or Post-eruptive?"],"prefix":"10.1177","volume":"69","author":[{"given":"A.","family":"Groeneveld","sequence":"first","affiliation":[{"name":"Department of Community Dental Health and Epidemiology, Netherlands Institute for Preventive Health Care, PO Box 124, 2300 AC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.M.J.","family":"Van Eck","sequence":"additional","affiliation":[{"name":"Department of Community Dental Health and Epidemiology, Netherlands Institute for Preventive Health Care, PO Box 124, 2300 AC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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