{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:27:30Z","timestamp":1777811250898,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>\n                    Orthodontic tooth movement requires remodeling of periodontal tissues, especially alveolar bone. 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    , the active form of vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    , is known to be a potent stimulator of osteoclastic bone resorption. The purpose of this study was to investigate the effect of local application of 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    on osteoclast numbers induced by experimental tooth movement. A piece of orthodontic elastic band was inserted between the first and second upper molars of male Wistar rats weighing about 200 g each. Twenty \u03bcL of 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    (10\n                    <jats:sup>-12<\/jats:sup>\n                    -10\n                    <jats:sup>-7<\/jats:sup>\n                    mol\/L) was injected locally into the submucosal palatal area of the root bifurcation of the right first molar. The left side was injected with phosphate-buffered saline (PBS). The number of osteoclasts was counted in a 700 x 1050 \u03bcm\n                    <jats:sup>2<\/jats:sup>\n                    area of the interradicular septum. The local injection of 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    caused a dose-dependent increase in osteoclast number. The effect of 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    reached a response plateau at 10\n                    <jats:sup>-10<\/jats:sup>\n                    mol\/L when greater than a threefold rise in osteoclast number was attained compared with the PBStreated controls. While the insertion of a piece of elastic band for three days induced a significant increase in osteoclasts in the alveolar bone, daily injections of 20 \u03bcL of 10\n                    <jats:sup>-10<\/jats:sup>\n                    mol\/M 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    for three days markedly stimulated the numbers of osteoclasts induced by the insertion of an elastic band. 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    was apparently synergistic with mechanical stimuli, resulting in enhancement of the numbers of osteoclasts induced by mechanical stimuli alone. These findings suggest that the local application of 1,25-(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    acted directly to increase osteoclast number and to potentiate osteoclastic bone resorption induced by mechanical stimuli.\n                  <\/jats:p>","DOI":"10.1177\/00220345920710010901","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"53-59","source":"Crossref","is-referenced-by-count":62,"title":["The Effect of Local Application of 1,25-Dihydroxycholecalciferol on Osteoclast Numbers in Orthodontically Treated Rats"],"prefix":"10.1177","volume":"71","author":[{"given":"T.","family":"Takano-Yamamoto","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sakuda","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.19.5907"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553753"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040880311"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1965.0226"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(88)90052-2"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(80)90222-5"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90076-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.45.070176.003215"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556637"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010759"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-6-2293"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408081"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402163100701"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(79)90043-8"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1016\/S0021-9258(19)68933-7","volume":"256","author":"Manolagas, S.C.","year":"1981","journal-title":"J Biol Chem"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1016\/S0021-9258(19)85505-9","volume":"255","author":"Manolagas, S.C.","year":"1980","journal-title":"J Biol Chem"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405070"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113089"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112292"},{"key":"atypb20","unstructured":"Meunier, P.J.; Edouard, C.; Arlot, M.; Lejeune, E.; Alexander, C.; and Leroy, G. (1979): Effects of 1,25 dihydroxyvitamin D on Bone Mineralization . In: Molecular Endocrinology, I. MacIntyre and M. Szelke, Eds. Amsterdam: Elsevier North Holland Biomedical Press, pp. 283-292."},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405028"},{"key":"atypb22","first-page":"237","volume":"28","author":"Queille, M.L.","year":"1978","journal-title":"Biomedicine"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4023.768"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1126\/science.168639"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(80)90126-9"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(73)90353-9"},{"key":"atypb27","unstructured":"Stumpf, W.E.; Madhabanada, S.; and Deluca, H.F. (1981): Sites of Action of 1,25-(OH)2 Vitamin D3 Identified by Thaw-mount Autoradiography. In: Hormonal Control of Calcium Metabolism, D.V. Cohn, R.V. Talmage, and J.L. Matthews , Eds. Amsterdam: Excerpta Medica , pp. 222-229."},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(71)90163-9"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1177\/00220345540330040701"},{"key":"atypb30","first-page":"459","volume":"92","author":"Weisbrode, S.E.","year":"1978","journal-title":"Am J Pathol"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1177\/00220345800590101301"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1177\/00220345820610121501"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(84)90091-5"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345920710010901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345920710010901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:02:12Z","timestamp":1777496532000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345920710010901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1177\/00220345920710010901"],"URL":"https:\/\/doi.org\/10.1177\/00220345920710010901","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}