{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:42:26Z","timestamp":1780587746023,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>The effects of Vitamin D deficiency rickets on the formation of mineralized dental tissues were studied in a breed of pigs which had moderate and marked hypocalcemia because of an inherited defect in the renal production of the biologically-active Vitamin D metabolites. Affected piglets developed classical symptoms of rickets which were fatal unless Vitamin D supplements were given. The dissected mandibles of homozygous (rickets) and heterozygous (normal) pigs were photographed and radiographed. Compared with those of normal pigs, the mandibles of homozygous pigs demonstrated slowed development\/eruption of permanent teeth, under-mineralized bone, underdeveloped dentin (enlarged pulp chambers), interglobular dentin, and enamel hypoplasia. Enamel defects in rachitic pig teeth were difficult to observe radiographically, but could be detected visually and by SDS-PAGE analysis of the enamel protein components of developing and maturing enamel. There was significant retention of amelogenins in the enamel maturation zones of developing molars taken from rachitic pigs, but there was no obvious difference in the patterns of amelogenin processing.<\/jats:p>","DOI":"10.1177\/00220345920710020101","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"346-352","source":"Crossref","is-referenced-by-count":26,"title":["The Effects of Hypocalcemia\/Hypophosphatemia on Porcine Bone and Dental Hard Tissues in an Inherited Form of Type 1 Pseudo-Vitamin D Deficiency Rickets"],"prefix":"10.1177","volume":"71","author":[{"given":"H.","family":"Limeback","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, University of Toronto, 124 Edward St., Room 455, Toronto, ON, Canada M5G 1G6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schlumbohm","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Veterinary Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sen","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of Toronto, 124 Edward St., Room 455, Toronto, ON, Canada M5G 1G6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nikiforuk","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of Toronto, 124 Edward St., Room 455, Toronto, ON, Canada M5G 1G6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650101401"},{"key":"atypb2","volume-title":"Tooth Enamel V","author":"Fearnhead, R.W.","year":"1990"},{"key":"atypb3","volume-title":"Die BedentungvonTiermodellen bei der Erforschung menschlicher Erkrankungen, drei Beispiele von Erkrankungen des Skelets","author":"Harmeyer, J.","year":"1991"},{"key":"atypb4","first-page":"117","volume":"7","author":"Harmeyer, J.","year":"1982","journal-title":"Exp Biol Med"},{"key":"atypb5","unstructured":"Harmeyer, J. and Kaune, R. (1990): Two Unique Animal Models for the Study of Human Metabolic Bone Diseases. In: Farm Animals in Biochemical Research. Advances in Animal Breeding and Genetics, V. Pliska and G. Stranzinger, Eds. Hamburg: Paul Parey, pp. 111-130."},{"key":"atypb6","unstructured":"Kaune, R. and Harmeyer, J. (1985): Metabolism of Vitamin D in Pigs with Pseudo Vitamin D-deficiency Rickets after Treatment with High Doses of Vitamin D3. In: Vitamin D. A Chemical, Biochemical and Clinical Update, A.W. Norman, K. Schaefer , H.G. Grigoleit, and D. von Herrath, Eds. New York: Walter de Gruyter & Co., pp. 35-36."},{"key":"atypb7","first-page":"6","volume":"100","author":"Kaune, R.","year":"1987","journal-title":"Typ I, Berl M\u00fcnch Tier\u00e4rztl Wschr"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(90)90209-S"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(79)90014-6"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80580-X"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1042\/bj2560965"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1159\/000146306"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556835"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345920710020101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345920710020101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:02:35Z","timestamp":1777496555000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345920710020101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1177\/00220345920710020101"],"URL":"https:\/\/doi.org\/10.1177\/00220345920710020101","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}