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Agents discussed in this paper are those most frequently evaluated in recent studies and include chlorhexidine, essential oils, triclosan, sanguinarine, fluorides, oxygenating agents, quaternary ammonium agents, prebrushing rinses, enzymes, and antibiotics. Of the agents discussed, the greatest effect on the reduction of plaque and gingivitis can be expected from chlorhexidine, essential oils, and triclosan-containing products. These chemical agents vary in dosage form and include mouthrinses, gels, and dentifrices. Some may also be of value as irrigants. Adverse effects vary according to the chemical agent and include poor taste, burning sensation of oral tissue, staining of teeth and soft tissues, excess supragingival calculus, oral lesions in young patients, and allergic reactions. When a product is selected for a patient, consideration should be given to necessity, efficacy, adverse effects, and cost-effectiveness.<\/jats:p>","DOI":"10.1177\/00220345920710071701","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T21:14:56Z","timestamp":1290978896000},"page":"1450-1454","source":"Crossref","is-referenced-by-count":48,"title":["Agents for the Management of Plaque and Gingivitis"],"prefix":"10.1177","volume":"71","author":[{"given":"S.G.","family":"Ciancio","sequence":"first","affiliation":[{"name":"Department of Periodontology, Center for Clinical Dental Studies, State University of New York at Buffalo, Buffalo, New York 14214"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01434.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1159\/000260704"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8177(86)24021-0"},{"key":"atypb4","first-page":"21","volume":"11","author":"Bailey L.","year":"1989","journal-title":"Clin Prev Dent"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1990.0033"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/00220345880670021501"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196749010-00003"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1971.0023"},{"key":"atypb9","first-page":"6","volume":"2","author":"Carter HG","year":"1975","journal-title":"J Prev Dent"},{"key":"atypb10","unstructured":"Ciancio SG (1987). 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