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Its key feature is a dietary carbohydrate-induced enrichment of the plaque microbiota with organisms such as the mutans streptococci and lactobacilli which causes an increase of plaque's pH-lowering and cariogenic potential. The shift in the plaque proportions of these organisms appears to be related to their relatively high acid tolerance.<\/jats:p>\n                  <jats:p>A large body of evidence also supports a major effect of saliva on caries development. Integration of salivary effects with the concept of caries as a dietary carbohydrate-modified bacterial infectious disease suggests a broader concept whichincludes a major role of saliva in the regulation of the exposure of tooth surfaces to carbohydrate and of plaque acidity and, hence, the microbial composition and the pH-lowering and cariogenic potential of dental plaque. It is proposed that caries occurs preferentially in dentition sites characterized by a relatively high exposure to carbohydrate and diminished salivary effects. Some implications of this concept are discussed.<\/jats:p>","DOI":"10.1177\/00220345940730031301","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T11:09:42Z","timestamp":1500376182000},"page":"672-681","source":"Crossref","is-referenced-by-count":437,"title":["Role of Micro-organisms in Caries Etiology"],"prefix":"10.1177","volume":"73","author":[{"given":"J.","family":"van Houte","sequence":"first","affiliation":[{"name":"Forsyth Dental Center, Department of Oral Microbiology, 140 The Fenway, Boston, Massachusetts 02115"}]}],"member":"179","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345810600090101"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(61)90023-1"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690051701"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1990.tb00439.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680120301"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680090101"},{"key":"atypb7","unstructured":"Brown LR, Dreizen S., Handler S. 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