{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:33:53Z","timestamp":1777811633815,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>The etiology of myofascial tenderness and pain of masticatory muscles in humans is difficult to understand. Parafunctional oral habits such as tooth grinding or vigorous chewing are thought to be factors. The objective of this study was to determine if masticatory muscles are susceptible to weakness and injury induced by repetitive, dynamic, forced-lengthening contractions. Results would support the hypothesis that contraction-induced injuries could occur in hyperactive masticatory muscles of humans in response to parafunctional oral habits. Mice were anesthetized and randomly assigned to three groups: non-treated controls, treated by repetitive passive jaw opening, or treated by repetitive isometric tetanic contractions with lengthening by jaw opening. In each treatment group, masticatory muscle injury was evaluated by contractile tension, plasma creatine kinase, and muscle glycogen. Contractile tension was determined at different stimulation frequencies and was significantly decreased 5 min, 4 h, and 72 h after repetitive contraction\/lengthening. Plasma creatine kinase was significantly elevated at 4 but not at 72 h post-treatment in mice subjected to repetitive contraction\/lengthening. Masticatory muscle glycogen was not significantly different in any groups at 4 or 72 h post-treatment. These results indicate that contraction injuries can be induced in masticatory muscle of mice by forced lengthening contractions which simulate eccentric contractions.<\/jats:p>","DOI":"10.1177\/00220345950740020401","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"642-648","source":"Crossref","is-referenced-by-count":12,"title":["Weakness in Mouse Masticatory Muscles by Repetitive Contractions with Forced Lengthening"],"prefix":"10.1177","volume":"74","author":[{"given":"M.O.","family":"Hutchins","sequence":"first","affiliation":[{"name":"Physiology Section, Department of Basic Sciences, University of Texas Health Science Center at Houston Dental Branch, PO Box 20068, Houston, Texas 77225"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.S.","family":"Skjonsby","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Basic Sciences, University of Texas Health Science Center at Houston Dental Branch, PO Box 20068, Houston, Texas 77225"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.","family":"Brazeau","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, University of Florida, College of Pharmacy, Gainesville, Florida 32610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.K.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Basic Sciences, University of Texas Health Science Center at Houston Dental Branch, PO Box 20068, Houston, Texas 77225"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Basic Sciences, University of Texas Health Science Center at Houston Dental Branch, PO Box 20068, Houston, Texas 77225"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.1.80"},{"key":"atypb2","first-page":"25","volume":"46","author":"Brazeau G.","year":"1992","journal-title":"J Parenter Sci Technol"},{"key":"atypb3","unstructured":"Christensen L. (1986). Pains from the jaws muscles in children and adults . In: Orthodontics, state of the art essence of the science . Graber LW, editor. St. Louis, MO: C.V. 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