{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:48:25Z","timestamp":1779155305589,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>The dental follicle, a loose connective tissue sac which surrounds the unerupted tooth, is required for eruption to occur. Injection of colony-stimulating factor-1 (CSF-1) will accelerate molar eruption in rats, as well as stimulate tooth eruption in osteopetrotic rats. Utilizing in situ hybridization and reverse- transcription polymerase chain-reaction techniques, we show here that CSF-1 mRNA is present in vivo in the dental follicle of the first mandibular molar of the rat. Analysis of the molars from day 0 through day 10 post-natally demonstrates that the maximal expression of CSF-1 mRNA is at day 3 post-natally. Immunostaining also reveals that the CSF-1 mRNA is translated, with immunostaining for the CSF-1 itself, being heavy in early post-natal days and absent by day 9 post-natally. In view of the fact that there is a maximal influx of mononuclear cells (monocytes) into the dental follicle at day 3 post-natally-an influx which increases the numbers of osteoclasts needed to form a tooth eruption pathway-it is probable that the maximal expression of CSF-1 mRNA by day 3 post-natally contributes to this monocyte influx. Thus, this study establishes a relationship among a molecule (CSF-1), cell (monocyte), and tissue (dental follicle) that appear to play a major role in tooth eruption.<\/jats:p>","DOI":"10.1177\/00220345950740090801","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1551-1557","source":"Crossref","is-referenced-by-count":59,"title":["Transcription and Translation of CSF-1 in the Dental Follicle"],"prefix":"10.1177","volume":"74","author":[{"given":"G.E.","family":"Wise","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy and Cell Biology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803-8408"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Cell Biology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803-8408"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Cell Biology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803-8408"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.17.6179"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1980.tb00377.x"},{"key":"atypb3","unstructured":"Cielinski MJ, Jolie M., Wise CE, Ando DG, Marks SC Jr (1994). Colony-stimulating factor-1 (CSF-1) is a potent stimulator of tooth eruption in the rat. In: Biological mechanisms of tooth eruption, resorption and replacement by implants. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 429-436."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-146-38146"},{"key":"atypb5","author":"Falkenburg JHF","year":"1990","journal-title":"J Immunol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050716"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.3.860.bloodjournal723860"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07829.x"},{"issue":"1","key":"atypb9","first-page":"S199","volume":"6","author":"Hofstetter W.","year":"1991","journal-title":"J Bone Min Res"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90125-R"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1976.tb01760.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001490212"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90105-5"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001680303"},{"key":"atypb15","unstructured":"Marks SC Jr, Cielinski MJ, Sundquist K., Wise GE, Gorski JP (1994). The of bone resorption in tooth eruption. In: The biological of of tooth eruption, resorption and replacement by implants. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 483-488."},{"key":"atypb16","first-page":"311","volume":"1","author":"Rothwell VM","year":"1987","journal-title":"Oncogene Res"},{"key":"atypb17","first-page":"154","volume":"17","author":"Shadle PJ","year":"1989","journal-title":"Exp Hematol"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116762"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240210206"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4828"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680021001"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00893.x"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90138-4"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00461.x"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(90)90026-7"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001950206"},{"key":"atypb27","unstructured":"Wise GE, Lin F., Marks SC Jr, Gorski JP (1994a). The molecular basis of tooth eruption. In: The biological mechanisms of tooth eruption, resorption and replacement by implants. Davidovitch Z, editor. 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