{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:33:29Z","timestamp":1777811609014,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:p>The involvement of transglutaminase C (TGase C) in morphogenesis and cytodifferentiation during glandular tubule formation was addressed by immunolocalization of the protein at different stages of prenatal human submandibular gland development in 100 fetuses and 20 adult salivary glands. Immunocytochemical detection was carried out using a monospecific antibody to TGase C. The results showed TGase C reactivity in both acini and ducts early in development (from 10 to 14 weeks), followed by a marked increase in ductal activity and a decline in acinar activity up to 32 weeks. During the peak of reactivity at 25 to 32 weeks, staining was concentrated in the apical ends of the columnar cells. In the adult, staining was weakly and diffusely distributed in the striated and excretory ducts. Western blot analysis of the cellular extracts of pooled samples from various stages of salivary gland development showed a single strong band at 76 kDa early in development. This band became weaker after 32 weeks of prenatal development and in the adult. These findings of transient high expression of TGase C, which coincide with the development of tubulo-alveolar structure, suggest that TGase C may play a role in morphogenesis in human salivary gland development.<\/jats:p>","DOI":"10.1177\/00220345950740111501","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1812-1816","source":"Crossref","is-referenced-by-count":5,"title":["Expression of Transglutaminase C during the Prenatal Development of Human Submandibular Glands"],"prefix":"10.1177","volume":"74","author":[{"given":"S.K.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.J.","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.C.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.I.","family":"Chung","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Development and Oncology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"atypb1","volume-title":"Oral development and histology: structure and function of salivary glands","author":"Avery JK","year":"1987"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"22501","DOI":"10.1016\/S0021-9258(18)54600-7","volume":"266","author":"Barsigian C.","year":"1991","journal-title":"J. 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