{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:38:54Z","timestamp":1777811934183,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>\n                    Although a functional role for serotonin (5-hydroxytryptamine, 5-HT) has been defined in the salivary glands of some lower species, relatively few data supporting a role for 5-HT in the regulation of mammalian salivary glands have been presented. Our initial results from polymerase chain reaction studies in cells of mammalian submandibular gland origin using consensus sequence primers from G protein-coupled receptors suggested the presence of mRNA for a 5-HT receptor in these cells. Based on this observation, the question of a role for 5-HT in mammalian submandibular gland function was re-addressed, using isolated, perfused rat submandibular glands and dispersed-cell aggregates from this gland. In perfused glands, 5-HT decreased the rate of saliva flow initiated by acetylcholine by about 50% and increased the amount of protein in the saliva two-fold. In dispersed-cell aggregates, 5-HT elicited a concentration-dependent increase in the accumulation of adenosine 3',5' monophosphate (cyclic AMP; EC\n                    <jats:sub>50<\/jats:sub>\n                    = 660 \u00b1 110 nM). In addition, functional studies, as well as radioligand binding experiments, indicated that the effects of 5-HT are independent of beta-adrenoceptors. Accumulation of cAMP in gland cells was consistent with a direct action of 5-HT on adenylyl cyclase. Similar cyclic AMP responses to 5-HT were observed in cells isolated from mouse and opossum submandibular glands and rat sublingual and parotid glands. Our findings suggest the presence of a 5-HT receptor in mammalian salivary glands coupled to the stimulation of adenylyl cyclase and, at least in rat submandibular gland, involved in modifying the volume and protein content of saliva.\n                  <\/jats:p>","DOI":"10.1177\/00220345960750031101","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"935-941","source":"Crossref","is-referenced-by-count":18,"title":["A Regulatory Role in Mammalian Salivary Glands for 5-Hydroxytryptamine Receptors Coupled to Increased Cyclic AMP Production"],"prefix":"10.1177","volume":"75","author":[{"given":"J.T.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Pharmacology, M561 Health Sciences Center, University of Missouri-Columbia, Columbia, Missouri 65212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"National Eye Institute, Building 10 Room 10B17, 9000 Rockville Pike, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Camden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1981.tb16809.x"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0022-3565(25)32642-X","volume":"218","author":"Bylund DB","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1974.tb05743.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680010901"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.261.3.C490"},{"key":"atypb6","first-page":"207","volume":"1","author":"Harper JF","year":"1975","journal-title":"J Cyclic Nucleotide Res"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(25)06783-3","volume":"46","author":"Hoyer D.","year":"1994","journal-title":"Pharmacol Rev"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01982861"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01952223"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00023-I"},{"key":"atypb12","volume-title":"Analysis of membrane polypeptides by two-dimensional polyacrylamide gel electrophoresis","author":"Roberts RM","year":"1984"},{"key":"atypb13","unstructured":"New York: Alan R. Liss Inc., pp. 61-113."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.1.367"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(90)90170-F"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90050-I"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345960750031101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345960750031101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:04:54Z","timestamp":1777496694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345960750031101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1177\/00220345960750031101"],"URL":"https:\/\/doi.org\/10.1177\/00220345960750031101","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}