{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:39:33Z","timestamp":1777811973132,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1996,4,1]],"date-time":"1996-04-01T00:00:00Z","timestamp":828316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>\n                    Virulence ot herpes simplex virus (HSV) in mice has been demonstrated to be dependent on the site of infection. In this experiment, pathogenesis of HSV was studied in 2 different routes of infection in a mouse model system. When BALB\/c mice were infected with 5 x 103 plaque-forming units (PFU) of virulent HSV type 1 Miyama GC+ strain (HSV-1-GC+) intraperitoneally, all mice were dead in 6 to 9 days. HSV-1-GC+ was recovered from organs such as the cerebrum, cerebellum, brainstem, and spleen 2 to 5 days after infection, but not from other organs such as trigeminal ganglia. However, if mice were infected in the maxillary gingiva with 1.0 x 107 PFU of HSV-1-GC+, all mice survived. HSV-1-GC\n                    <jats:sup>+<\/jats:sup>\n                    was recovered from the trigeminal ganglia and brainstem 2 to 5 days after infection, but not from other organs tested. When mice were infected in maxillary gingiva with HSV-1-GC+, followed by the intraperitoneal injection of 6 mg of cyclophosphamide 72 hrs after virus infection, all mice were dead within days. Immunofluorescent and hematoxylin-eosin staining of gingival tissue sections revealed that when mice were infected in maxillary gingiva with HSV-1-GC+, 3 times as many \u03b3\u03b4 T-cells and 5 times as many polymorphonuclear cells can be detected in sections of maxillary gingiva when compared with non-infected mice. These data show that the gingiva of mice is considerably more resistant to infection with HSV, compared with the peritoneal cavity, and suggest the possible presence of an oral defense mechanism which might be different from that in the peritoneal cavity.\n                  <\/jats:p>","DOI":"10.1177\/00220345960750041201","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"974-979","source":"Crossref","is-referenced-by-count":3,"title":["Highly Virulent Strains of Herpes Simplex Virus Fail to Kill Mice Following Infection via Gingival Route"],"prefix":"10.1177","volume":"75","author":[{"given":"Y.","family":"Monma","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Tohoku University School of Dentistry, Sendai 980, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Building 30, Room 229, Bethesda, MD 20892, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mayama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tohoku University School of Dentistry, Sendai 980, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kamiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Tohoku University School of Dentistry, Sendai 980, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tokyo Medical and Dental University, School of Medicine2, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.4049\/jimmunol.153.11.5133","volume":"153","author":"Bukowski JF","year":"1994","journal-title":"J Immunol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-55-1-31"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311361"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220113"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706043162304"},{"key":"atypb6","first-page":"38","volume":"79","author":"Lundqvist C.","year":"1993","journal-title":"Immunology"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.4049\/jimmunol.153.5.2302","volume":"153","author":"Lundqvist C.","year":"1994","journal-title":"J Immunol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(92)90047-9"},{"key":"atypb9","first-page":"75","volume":"4","author":"Nii S.","year":"1961","journal-title":"Biken's J"},{"key":"atypb10","first-page":"255","volume":"4","author":"Nii S.","year":"1961","journal-title":"Biken's J"},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/infdis\/127.1.117","volume":"127","author":"Notkins AL","year":"1973","journal-title":"J Infect Dis"},{"key":"atypb12","first-page":"493","volume":"27","author":"Reed LJ","year":"1938","journal-title":"Am J Hyg"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.34.3.655-661.1981"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.22.3.752-757.1978"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/00220345890680030701"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.61.8.2515-2522.1987"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.64.5.2187-2192.1990"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345960750041201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345960750041201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:05:05Z","timestamp":1777496705000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345960750041201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1177\/00220345960750041201"],"URL":"https:\/\/doi.org\/10.1177\/00220345960750041201","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}