{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:19:25Z","timestamp":1777810765189,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p>\n                    The aim of this study was to test the hypothesis that the chewing of xylitol- or xylitol\/sorbitol-containing chewing gum reduces plaque formation and the acidogenic potential of dental plaque. Thirty healthy volunteers aged from 19 to 28 yrs were randomly allocated to one of three test groups, chewing either xylitol-, xylitol\/sorbitol-, or sucrose-sweetened gums. A three-day plaque accumulation period of no oral hygiene was instituted prior to and at the termination of the chewing gum program, which lasted 33 days. Plaque quantity was assessed on the basis of protein content of individual plaque samples collected by a standardized technique. Acidogenic potential of individual baseline and test plaque samples was assessed by the quantity of various organic acids formed from D-(U-\n                    <jats:sup>14<\/jats:sup>\n                    C)glucose. Identification of extracellular and intracellular metabolites was performed by HPLC. Statistical evaluation of data was performed according to paired comparisons of individual baseline and post-chewing data. Plaque formation, acidogenic potential, and glycolytic profiles were similar at baseline and after the gum-chewing periods. Also, there was no intracellular accumulation of glycolytic metabolites within the plaque bacteria to indicate the inhibition of glycolysis. The study thus leads to the conclusion that, in young adults with low caries experience, exposure of the oral cavity to acceptable doses of xylitol or xylitol and sorbitol has no effect on the microbial deposits on the teeth.\n                  <\/jats:p>","DOI":"10.1177\/00220345980770071001","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1547-1552","source":"Crossref","is-referenced-by-count":27,"title":["The Effects of Xylitol-containing Chewing Gums on Dental Plaque and Acidogenic Potential"],"prefix":"10.1177","volume":"77","author":[{"given":"A.Aa.","family":"Scheie","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, University of Oslo, PO Box 1052 Blindern, 0316 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Fejerskov","sequence":"additional","affiliation":[{"name":"Department of Dental Pathology, Operative Dentistry and Endodontics, Royal Dental College, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Department of Dental Pathology, Operative Dentistry and Endodontics, Royal Dental College, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1159\/000261516"},{"key":"atypb2","first-page":"89","volume":"92","author":"Assev S.","year":"1984","journal-title":"Acta Path Microbiol Immunol Scand"},{"key":"atypb3","first-page":"231","volume":"94","author":"Assev S.","year":"1986","journal-title":"Acta Path Microbiol Immunol Scand"},{"key":"atypb4","first-page":"97","volume":"94","author":"Assev S.","year":"1986","journal-title":"Acta Path Microbiol Immunol Scand"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00092.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660031101"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1159\/000415563"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.3109\/00016359409029065"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1159\/000419465"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1159\/000260652"},{"key":"atypb11","unstructured":"Carlsson J., Hamilton I. 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(1995). Xylitol chewing gums and caries rates: A 40-month cohort study. J Dent Res 74:1904-1913. Makinen KK, Hujoel PP, Bennett CA, Isotupa KP, Makinen PL, Allen P (1996a). Polyol chewing gums and caries rates in primary dentition: A 24-month cohort study. Caries Res 30:408-417.","DOI":"10.1177\/00220345950740121501"},{"key":"atypb24","first-page":"22","volume":"46","author":"Makinen KK","year":"1996","journal-title":"Int Dent J"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.3109\/00016357509004630"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1159\/000260278"},{"key":"atypb27","unstructured":"Park KK, Hernandez D, Schemehom BR, Katz BP, Stookey GK, Sanders PG, et al. (1995). Effect of chewing gums on plaque pH after a sucrose challenge. J Dent Child May-June:180-186. Scheinin A, Soderling E (1986). Carbohydrate sweeteners and dental caries. 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