{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:20:54Z","timestamp":1777810854997,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>Occlusal alterations may result in changes in the functional performance of masticatory muscles. In this study, we set up an experimental model in rats to examine whether masticatory muscle abnormalities occur after a malocclusion is induced. Rats underwent unilateral amputation of the molar cusps to simulate an occlusal wear situation. The masseter muscles ipsilateral and contralateral to the amputated molars were excised at different experimental times. Sham-operated rats were used as controls. The tissue samples were studied by light and electron microscopy and morphometry. Tissue calcium content, a biochemical index of muscle injury, was also determined. The results show that occlusal dysfunction leads to microvessel constriction and clear-cut morphologic damage of muscular fibers and blood capillary endothelium, as well as to elevation of tissue calcium content, in the ipsilateral masseter muscle. These changes are likely related to muscle fatigue and ischemia. The early signs of injury do not involve the entire muscle but are mostly restricted to tissue areas rich in type I (slow) muscle fibers, which are characterized by a predominantly aerobic metabolism. The muscle damage becomes more extended and severe with time. On the other hand, the contralateral muscles show only slight alterations which are reversible with time, possibly due to an adaptive response.<\/jats:p>","DOI":"10.1177\/00220345990780111101","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1735-1744","source":"Crossref","is-referenced-by-count":49,"title":["Morphologic and Biochemical Changes of the Masseter Muscles Induced by Occlusal Wear: Studies in a Rat Model"],"prefix":"10.1177","volume":"78","author":[{"given":"D.","family":"Bani","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bani","sequence":"additional","affiliation":[{"name":"Department of Odontostomatology, School of Dentistry, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Department of Odontostomatology, School of Dentistry, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90248-2"},{"key":"atypb2","first-page":"1367","volume":"152","author":"Bani D.","year":"1998","journal-title":"Am j Pathol"},{"key":"atypb3","first-page":"43","volume":"17","author":"Bennett RM","year":"1990","journal-title":"Adv Pain Res Ther"},{"key":"atypb4","volume-title":"Systematic of musculoskeletal disorders related to masticatory dysfunctions","author":"Bergamini M.","year":"1992"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/15.3.121"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1981.tb00502.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00845520"},{"key":"atypb8","volume-title":"Evaluation, diagnosis and treatment of occlusal problems","author":"Dawson P.","year":"1974"},{"key":"atypb9","first-page":"1","volume":"12","author":"Eriksson PO","year":"1982","journal-title":"Swed Dent J"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(83)90034-1"},{"key":"atypb11","doi-asserted-by":"crossref","unstructured":"Coldspink G. (1983). Alterations in myofibril size and structure during growth, exercise, and changes in environmental temperature. In: Handbook of physiology. Section 10, Skeletal muscle. Peachey LD, Adrian RH, Geiger SR, editors. 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