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The current study profiled stigmas reported by women in jail with substance use histories and investigated the relationship between the number of overlapping stigmas reported and perceptions of substance use stigma. Exploratory analyses examined the relationship between each individual stigma and substance use stigma. Findings suggest that individuals who reported more stigmas reported higher substance use stigma scores. Additionally, exploratory results suggested that rurality, transactional sex, injection drug use, methamphetamine use, being diagnosed with a mood disorder, experiencing sexual abuse or assault, and child custody loss were uniquely associated with increased substance use stigma. 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