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Analysis of data from Miami\u2013Dade County, Florida, shows that young adults reporting same-sex contact have higher levels of depressive symptoms and drug use than those without such contact, but that different processes explain the disparities in the two outcomes. A substantial portion of the gap in depressive symptoms is explained by sexual minorities\u2019 higher levels of stress exposure and their lower levels of family support and psychological resources. The gap in drug use is not explained by these processes, but is partially explained by self-exploratory attitudes and permissiveness of drug use in social networks. 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