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Here we report that, in rat pancreas, intense GFAP-like immunoreactivity is detectable in a subpopulation of endocrine cells located in the periphery of the islet of Langerhans. In addition, staining appeared to be preferentially localized to the apical pole of the cells. Two different polyclonal antibodies were employed in this study, with analogous results. Staining of consecutive sections with anti-GFAP, anti-glucagon, and anti-somatostatin antibodies demonstrates that GFAP-like immunoreactivity is present in glucagon-secreting cells. The relevance of this finding is discussed.<\/jats:p>","DOI":"10.1177\/002215540004800211","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:17:54Z","timestamp":1301627874000},"page":"259-265","source":"Crossref","is-referenced-by-count":14,"title":["Glial Fibrillary Acidic Protein (GFAP)-like Immunoreactivity in Rat Endocrine Pancreas"],"prefix":"10.1177","volume":"48","author":[{"given":"Mar\u00ec","family":"Regoli","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Orazioli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Gerli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Siena, Siena, 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