{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:22:43Z","timestamp":1790893363521,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>SUMMARY We studied the involvement of the apoptotic mechanism(s) in cell differentiation in the developing male rat submandibular gland using the TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick-labeling) assay in combination with light and electron microscopy. Whereas the proacinar cells were completely transformed into acinar cells within 2 weeks after birth, starting on postnatal Day 21, the terminal tubule cells formed vacuoles that disappeared by postnatal Day 35. During this period, positive TUNEL reactivity was seen in the terminal tubule cells, and electron microscopic analysis showed that certain morphological features of apoptosis, including fragmentation of nuclei and the presence of apoptotic bodies in the cytoplasm, were present in and restricted to the terminal tubule cells. These results indicate that, in addition to an autophagocytosis-mediated mechanism, apoptosis may also be involved in reducing the number of terminal tubule cells during postnatal development in the submandibular gland.<\/jats:p>","DOI":"10.1177\/002215540004800513","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:17:54Z","timestamp":1301627874000},"page":"695-698","source":"Crossref","is-referenced-by-count":19,"title":["Morphological Aspects of the Postnatal Development of Submandibular Glands in Male Rats: Involvement of Apoptosis"],"prefix":"10.1177","volume":"48","author":[{"given":"Hiroyuki","family":"Hayashi","sequence":"first","affiliation":[{"name":"Departments of Oral Histology (HH) and Pathology (SO), Kanagawa Dental College, Yokosuka, Japan; Departments of Physiology (KW) and Anatomy (MO), Gifu University School of Medicine, Gifu, Japan; and Department of Anatomy (IN), Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Ozono","sequence":"additional","affiliation":[{"name":"Departments of Oral Histology (HH) and Pathology (SO), Kanagawa Dental College, Yokosuka, Japan; Departments of Physiology (KW) and Anatomy (MO), Gifu University School of Medicine, Gifu, Japan; and Department of Anatomy (IN), Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Departments of Oral Histology (HH) and Pathology (SO), Kanagawa Dental College, Yokosuka, Japan; Departments of Physiology (KW) and Anatomy (MO), Gifu University School of Medicine, Gifu, Japan; and Department of Anatomy (IN), Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagatsu","family":"Ikuko","sequence":"additional","affiliation":[{"name":"Departments of Oral Histology (HH) and Pathology (SO), Kanagawa Dental College, Yokosuka, Japan; Departments of Physiology (KW) and Anatomy (MO), Gifu University School of Medicine, Gifu, Japan; and Department of Anatomy (IN), Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Onozuka","sequence":"additional","affiliation":[{"name":"Departments of Oral Histology (HH) and Pathology (SO), Kanagawa Dental College, Yokosuka, Japan; Departments of Physiology (KW) and Anatomy (MO), Gifu University School of Medicine, Gifu, Japan; and Department of Anatomy (IN), Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"bibr1-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.38.177"},{"key":"bibr2-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091780204"},{"key":"bibr3-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904700614"},{"key":"bibr4-002215540004800513","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/0270-9139(95)90071-3","volume":"21","author":"Grasl-Kraupp B","year":"1995","journal-title":"Hepatology"},{"key":"bibr5-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225529"},{"key":"bibr6-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1076\/ejom.34.3.0149"},{"key":"bibr7-002215540004800513","first-page":"151","volume":"17","author":"Hayashi H","year":"1989","journal-title":"Bull Kanagawa Dent Coll"},{"key":"bibr8-002215540004800513","first-page":"41","volume":"25","author":"Ito Y","year":"1990","journal-title":"Kanagawa Shigaku"},{"key":"bibr9-002215540004800513","first-page":"187","volume":"15","author":"Klein RM","year":"1982","journal-title":"Cell Tissue Kinet"},{"key":"bibr10-002215540004800513","first-page":"287","volume":"93","author":"Leeson CR","year":"1959","journal-title":"J Anat"},{"key":"bibr11-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600910"},{"key":"bibr12-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61759-3"},{"key":"bibr13-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091820104"},{"key":"bibr14-002215540004800513","first-page":"459","volume":"123","author":"Srivastava HC","year":"1977","journal-title":"J Anat"},{"key":"bibr15-002215540004800513","volume-title":"Apoptosis: The Molecular Basis of Cell Death.","author":"Tomei AD","year":"1991"},{"key":"bibr16-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199207000-00002"},{"key":"bibr17-002215540004800513","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001460302"}],"container-title":["Journal of Histochemistry &amp; 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