{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:11:09Z","timestamp":1791418269344,"version":"4.3.3"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>\n                    The rat stomach is rich in endocrine cells. The acid-producing (oxyntic) mucosa contains ECL cells, A-like cells, and somatostatin (D) cells, and the antrum harbours gastrin (G) cells, enterochromaffin (EC) cells and D cells. Although chromogranin A (CgA) occurs in all these cells, its processing appears to differ from one cell type to another. Eleven antisera generated to different regions of rat CgA, two antisera generated to a human (h) CgA sequences, and one to a bovine (b) CgA sequence, respectively, were employed together with antisera directed towards cell-specific markers such as gastrin (G cells), serotonin (EC cells), histidine decarboxylase (ECL cells) and somatostatin (D cells) to characterize the expression of CgA and CgA-derived peptides in the various endocrine cell populations of the rat stomach. In the oxyntic mucosa, antisera raised against CgA\n                    <jats:sub>291\u2013319<\/jats:sub>\n                    and CGA\n                    <jats:sub>316\u2013321<\/jats:sub>\n                    immunostained D cells exclusively, whereas antisera raised against bCgA\n                    <jats:sub>82\u201391<\/jats:sub>\n                    and CgA\n                    <jats:sub>121\u2013128<\/jats:sub>\n                    immunostained A-like cells and D cells. Antisera raised against CgA\n                    <jats:sub>318\u2013349<\/jats:sub>\n                    and CgA\n                    <jats:sub>437\u2013448<\/jats:sub>\n                    immunostained ECL cells and A-like cells, but not D cells. In the antrum, antisera against CgA\n                    <jats:sub>291\u2013319<\/jats:sub>\n                    immunostained D cells, and antisera against CgA\n                    <jats:sub>351\u2013356<\/jats:sub>\n                    immunostained G cells. Our observations suggest that each individual endocrine cell type in the rat stomach generates a unique mixture of CgA-derived peptides, probably reflecting cell-specific differences in the post-translational processing of CgA and its peptide products. A panel of antisera that recognize specific domains of CgA may help to identify individual endocrine cell populations.\n                  <\/jats:p>","DOI":"10.1177\/002215540104900102","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:17:54Z","timestamp":1301627874000},"page":"9-18","source":"Crossref","is-referenced-by-count":36,"title":["Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach"],"prefix":"10.1177","volume":"49","author":[{"given":"Per","family":"Norl\u00e9n","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Physiological Sciences, University of Lund, Sweden, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Physiological Sciences, University of Lund, Sweden, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Maule","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodat T.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Hogg","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Harriott","sequence":"additional","affiliation":[{"name":"School of Biology and Biochemistry, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin F.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Hutton","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Boulder, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"H\u00e5kanson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Physiological Sciences, University of Lund, Sweden, The Queen's University of Belfast, Belfast, North Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"bibr1-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232233"},{"key":"bibr2-002215540104900102","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609031622"},{"key":"bibr3-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1042\/bj2980521"},{"key":"bibr4-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-1-174"},{"key":"bibr5-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050110"},{"key":"bibr6-002215540104900102","first-page":"471","volume":"32","author":"Buffa R","year":"1988","journal-title":"Bas Appl Histochem"},{"key":"bibr7-002215540104900102","first-page":"27","volume-title":"The Stomach as an Endocrine Organ.","author":"Capella C","year":"1991"},{"key":"bibr8-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500540"},{"key":"bibr9-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(96)00227-6"},{"key":"bibr10-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00267079"},{"key":"bibr11-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80266-J"},{"key":"bibr12-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(98)00047-8"},{"key":"bibr13-002215540104900102","first-page":"197","volume-title":"The Stomach as an Endocrine Organ.","author":"Dockray GJ","year":"1991"},{"key":"bibr14-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1985.tb00040.x"},{"key":"bibr15-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90657-2"},{"key":"bibr16-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1990.tb00939.x"},{"key":"bibr17-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90191-5"},{"key":"bibr18-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb27189.x"},{"key":"bibr19-002215540104900102","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1016\/S0021-9258(19)39725-X","volume":"265","author":"Gorr SU","year":"1990","journal-title":"J Biol Chem"},{"key":"bibr20-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.52.Suppl_91"},{"key":"bibr21-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492340"},{"key":"bibr22-002215540104900102","first-page":"1171","volume-title":"The Physiology of the Gastrointestinal Tract.","author":"H\u00e5kanson R","year":"1994"},{"key":"bibr23-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90693-2"},{"key":"bibr24-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(90)90139-K"},{"key":"bibr25-002215540104900102","first-page":"1877","volume":"43","author":"Hogg RB","year":"1998","journal-title":"Dig Dis Sci"},{"key":"bibr26-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1042\/bj2440457"},{"key":"bibr27-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80036-X"},{"key":"bibr28-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80880-9"},{"key":"bibr29-002215540104900102","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0016-5085(84)90519-5","volume":"87","author":"Kubota H","year":"1984","journal-title":"Gastroenterology"},{"key":"bibr30-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.42.459"},{"key":"bibr31-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315853"},{"key":"bibr32-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1126\/science.382360"},{"key":"bibr33-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00933549"},{"key":"bibr34-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1177\/41.9.8354880"},{"key":"bibr35-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(83)90145-3"},{"key":"bibr36-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90721-X"},{"key":"bibr37-002215540104900102","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1016\/S0021-9258(17)43286-8","volume":"259","author":"O'Connor DT","year":"1984","journal-title":"J Biol Chem"},{"key":"bibr38-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1159\/000199395"},{"key":"bibr39-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500606"},{"key":"bibr40-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF00508649"},{"key":"bibr41-002215540104900102","first-page":"G925","volume":"260","author":"Sandvik AK","year":"1991","journal-title":"Am J Physiol"},{"key":"bibr42-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60982-1"},{"key":"bibr43-002215540104900102","first-page":"9","volume-title":"The Stomach as an Endocrine Organ.","author":"Sundler F","year":"1991"},{"key":"bibr44-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1038\/324476a0"},{"key":"bibr45-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF01003548"},{"key":"bibr46-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF01417947"},{"key":"bibr47-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760471"},{"key":"bibr48-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890062"},{"key":"bibr49-002215540104900102","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90154-5"}],"container-title":["Journal of Histochemistry &amp; Cytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/002215540104900102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/002215540104900102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/002215540104900102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:27:26Z","timestamp":1777501646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/002215540104900102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1177\/002215540104900102"],"URL":"https:\/\/doi.org\/10.1177\/002215540104900102","relation":{},"ISSN":["0022-1554","1551-5044"],"issn-type":[{"value":"0022-1554","type":"print"},{"value":"1551-5044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}