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In this study we examined the occurrence of activin A in nasal polyp tissues that present a combination of epithelium, mesenchyme, and vascular endothelium, with frequent massive hemopoietic infiltration. Anti-\u03b2A-chain antibodies strongly stained epithelial mucous glands and some endothelial cells, and diffusely stained the polyp stroma. Normal adult conchae were similarly stained, whereas activin A was not detected prenatally by immunostaining of nasal tissues. Staining specificity was substantiated by ligand competition assays. Detailed examination of the inflammatory polyp infiltrate showed that activin A staining was reduced in sites of focal infiltration of B-lymphoid cells. It is therefore implied that local accumulation of a large number of B-cells is associated with relatively low activin A expression.<\/jats:p>","DOI":"10.1177\/002215540104901006","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:17:54Z","timestamp":1301627874000},"page":"1245-1252","source":"Crossref","is-referenced-by-count":8,"title":["Reduced Expression of Activin A in Focal Lymphoid Agglomerates Within Nasal Polyps"],"prefix":"10.1177","volume":"49","author":[{"given":"Tsipi","family":"Shoham","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitan","family":"Yaniv","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumelia","family":"Koren","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka","family":"Gal","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshmi","family":"Parameswaran","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkadi","family":"Kravitz","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Geron","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Markovitz","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Lantzki","sequence":"additional","affiliation":[{"name":"Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dov","family":"Zipori","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"bibr1-002215540104901006","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1242\/dev.120.4.803","volume":"120","author":"Albano RM","year":"1994","journal-title":"Development"},{"key":"bibr2-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.49.29594"},{"key":"bibr3-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b24.x"},{"key":"bibr4-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.12.1361"},{"key":"bibr5-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(97)90062-4"},{"key":"bibr6-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90379-4"},{"key":"bibr7-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.16.2636"},{"key":"bibr8-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.1991.10.309"},{"key":"bibr9-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90342-5"},{"key":"bibr10-002215540104901006","doi-asserted-by":"publisher","DOI":"10.1038\/371487a0"},{"key":"bibr11-002215540104901006","unstructured":"Hellquist HB (1990) Pathology of the Nose and Paranasal Sinuses. 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