{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:44:54Z","timestamp":1777851894961,"version":"3.51.4"},"reference-count":81,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p>\n                    We previously found an abnormal deposition of an extracellular matrix glycoprotein, tenascin-C (TN-C), in human corneas with pseudophakic\/aphakic bullous keratopathy (PBK\/ABK). In this work, we studied cellular TN-C receptors in normal and PBK\/ABK corneas. Cryostat sections of normal and PBK\/ABK corneas were stained by immunofluorescence for TN-C receptors: \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    , \u03b1\n                    <jats:sub>8<\/jats:sub>\n                    , \u03b1\n                    <jats:sub>9<\/jats:sub>\n                    , \u03b1\n                    <jats:sub>V<\/jats:sub>\n                    \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    , \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    , and \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    integrins, and annexin II. \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    integrin mRNA levels were assessed by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) using \u03b2\n                    <jats:sup>2<\/jats:sup>\n                    -microglobulin gene to normalize the samples. In PBK\/ABK compared to normal corneas, relatively minor changes were observed for \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    and \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    integrins, and for annexin II. \u03b1\n                    <jats:sub>8<\/jats:sub>\n                    , \u03b1\n                    <jats:sub>9<\/jats:sub>\n                    , and \u03b2\n                    <jats:sup>6<\/jats:sup>\n                    subunits of TN-C receptors, \u03b1\n                    <jats:sub>8<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    \u03b1\n                    <jats:sub>9<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    , and \u03b1\n                    <jats:sub>V<\/jats:sub>\n                    \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    , respectively, were absent from normal central corneas but were found in the central epithelium of PBK\/ABK corneas. \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    integrin showed the most significant accumulation. It correlated best with the expression of TN-C rather than with the expression of other \u03b1\n                    <jats:sub>V<\/jats:sub>\n                    \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    ligands, fibronectin, and vitronectin. RT-PCR analysis also showed elevated levels of \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    mRNA in PBK\/ABK compared to normal corneas. Therefore, accumulation of TN-C in PBK\/ABK corneas was accompanied by an increased expression of its three binding integrins, especially \u03b1\n                    <jats:sub>V<\/jats:sub>\n                    \u03b2\n                    <jats:sub>6<\/jats:sub>\n                    in the corneal epithelium. The interaction of tenascin-C with these integrins may contribute to the fibrotic process that occurs in PBK\/ABK corneas.\n                  <\/jats:p>","DOI":"10.1177\/002215540104901102","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:17:54Z","timestamp":1301627874000},"page":"1341-1350","source":"Crossref","is-referenced-by-count":14,"title":["Increased Expression of Tenascin-C-binding Epithelial Integrins in Human Bullous Keratopathy Corneas"],"prefix":"10.1177","volume":"49","author":[{"given":"Alexander V.","family":"Ljubimov","sequence":"first","affiliation":[{"name":"Ophthalmology Research Laboratories, Burns & Allen Research Institute, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine Affiliate, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoosh","family":"Saghizadeh","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Laboratories, Burns & Allen Research Institute, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine Affiliate, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pytela","sequence":"additional","affiliation":[{"name":"Department of Medicine and Lung Biology Center\/San Francisco General Hospital, University of California San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Department of Medicine and Lung Biology Center\/San Francisco General Hospital, University of California San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Cristina","family":"Kenney","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Laboratories, Burns & Allen Research Institute, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine Affiliate, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"bibr1-002215540104901102","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80479-E"},{"key":"bibr2-002215540104901102","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1242\/jcs.108.6.2241","volume":"108","author":"Breuss J","year":"1995","journal-title":"J Cell Sci"},{"key":"bibr3-002215540104901102","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1016\/S0021-9258(18)42622-1","volume":"267","author":"Busk M","year":"1992","journal-title":"J Biol 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