{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:46:35Z","timestamp":1777851995511,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>KLH (Keyhole limpet hemocyanin) is highly immunogenic, and crossreactive epitopes occur widely in nature. In schistosomiasis, infected hosts generate antibodies reactive with KLH. This is of diagnostic importance but we lack detailed information on the immunogen-carrying molecules and their distribution in the worm. We used anti-KLH antibodies to localize cross-reacting epitopes in the various developmental stages of the parasite in experimental Schistosoma mansoni infection. The staining results show KLH crossreactivity in the life stages of the parasite. By immunoblotting we show that KLH-crossreactive antigenic epitopes in the parasite eggs are carbohydrates, also recognized by antibodies against soluble schistosome egg antigens. The localizations in the larval stages and in adult worms suggest that crossreacting antigenic epitopes are secretory products.<\/jats:p>","DOI":"10.1177\/002215540305101013","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:28:21Z","timestamp":1301628501000},"page":"1367-1373","source":"Crossref","is-referenced-by-count":14,"title":["Localization and Identification of\n                    <i>Schistosoma mansoni<\/i>\n                    \/KLH-crossreactive Components in Infected Mice"],"prefix":"10.1177","volume":"51","author":[{"given":"Cecilia","family":"Thors","sequence":"first","affiliation":[{"name":"Swedish Institute for Infectious Disease Control, Solna, Sweden, (SMI)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewert","family":"Linder","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden (MTC)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"bibr1-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1007\/BF01521345"},{"key":"bibr2-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90439-J"},{"key":"bibr3-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1982574345"},{"key":"bibr4-002215540305101013","doi-asserted-by":"publisher","DOI":"10.2307\/3279763"},{"key":"bibr5-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(99)00063-0"},{"key":"bibr6-002215540305101013","volume-title":"The Lectins: Properties, Functions, and Applications in Biology and Medicine","author":"Goldstein IJ","year":"1986"},{"key":"bibr7-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.865"},{"key":"bibr8-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182098003461"},{"key":"bibr9-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-4328(99)00036-0"},{"key":"bibr10-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(73)90004-0"},{"key":"bibr11-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000801"},{"key":"bibr12-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0002664X"},{"key":"bibr13-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1042\/bj20011678"},{"key":"bibr14-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(73)90198-8"},{"key":"bibr15-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90085-2"},{"key":"bibr16-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(86)90085-2"},{"key":"bibr17-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(90)90151-S"},{"key":"bibr18-002215540305101013","volume-title":"Molecular Biology and Immunology of the Adaptation and Development of Parasites","author":"Linder E","year":"1994"},{"key":"bibr19-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056286"},{"key":"bibr20-002215540305101013","doi-asserted-by":"publisher","DOI":"10.2307\/3283126"},{"key":"bibr21-002215540305101013","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1989.41.338"},{"key":"bibr22-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199709\/10)13:5<342::AID-SSU8>3.0.CO;2-D"},{"key":"bibr23-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5678"},{"key":"bibr24-002215540305101013","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.548"},{"key":"bibr25-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(95)02091-8"},{"key":"bibr26-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1998.00185.x"},{"key":"bibr27-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/10.6.601"},{"key":"bibr28-002215540305101013","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90654-1"}],"container-title":["Journal of Histochemistry &amp; 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