{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:42:46Z","timestamp":1777851766262,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>\n                    Using antibodies against the 31-kD and 70-kD subunits of vacuolar type H\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase (V-ATPase) and light microscopic immunocytochemistry, we have demonstrated the presence of this V-ATPase in rat submandibular gland. We have also investigated the adaptive changes of this transporter during acid-base disturbances such as acute and chronic metabolic acidosis or alkalosis. Our results show intracellularly distributed V-ATPase in striated, granular, and main excretory duct cells in controls, but no V-ATPase immunoreaction in acinar cells. Both acute and chronic metabolic acidosis caused a shift in V-ATPase away from diffuse distribution towards apical localization in striated and granular duct cells, suggesting that a V-ATPase could be involved in the regulation of acid\u2013base homeostasis. In contrast, during acidosis the main excretory duct cells showed no changes in the V-ATPase distribution compared to controls. With acute and chronic metabolic alkalosis, no changes in the V-ATPase distribution occurred.\n                  <\/jats:p>","DOI":"10.1177\/002215549804600112","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:11:07Z","timestamp":1301627467000},"page":"91-100","source":"Crossref","is-referenced-by-count":37,"title":["Immunolocalization of Vacuolar-type H\n                    <sup>+<\/sup>\n                    -ATPase in Rat Submandibular Gland and Adaptive Changes Induced by Acid\u2013Base Disturbances"],"prefix":"10.1177","volume":"46","author":[{"given":"Eleni","family":"Roussa","sequence":"first","affiliation":[{"name":"Anatomisches Institut, Medizinische Fakult\u00e4t, Universit\u00e4t des Saarlandes, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Th\u00e9venod","sequence":"additional","affiliation":[{"name":"II Physiologisches Institut, Medizinische Fakult\u00e4t, Universit\u00e4t des 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