{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:28:26Z","timestamp":1791232106837,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>SUMMARY We assessed the temporal-spatial distribution of hepatocyte nuclear factor-3\u03b2 (HNF-3\u03b2) in developing human lung and other foregut derivatives. Tissue from 31 fetuses (10-40 weeks) and 24 infants with hyaline membrane disease (HMD) or bronchopulmonary dysplasia (BPD) (2 days to 7 months) was studied. HNF-3\u03b2 was detected in nuclei of epithelial cells of trachea and of conducting and terminal airways at 10 weeks. Thereafter, epithelial nuclei were immunolabeled more widely in peripheral than proximal airways. HNF-3\u03b2 was confined to bronchiolo-alveolar portals and Type II cells in nonfetal lung. In infants with BPD, HNF-3 \u03b2 was expressed abundantly in regenerating epithelial cells at the periphery of lung lobules. HNF-3 \u03b2 was also detected in fetal esophagus, pancreas, duodenum, stomach, and gallbladder, suggesting that it is a marker for progenitor cells in foregut derivatives. The pattern of expression of HNF-3 \u03b2 in the lung was similar to that of thyroid transcription factor-1 (TTF-1) at all ages. The temporal-spatial patterns of HNF-3 \u03b2 and TTF-1 in the developing and regenerating lung are consistent with their proposed role in epithelial cell differentiation, regeneration, and surfactant protein gene expression.<\/jats:p>","DOI":"10.1177\/002215549804600809","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T03:11:07Z","timestamp":1301627467000},"page":"955-962","source":"Crossref","is-referenced-by-count":29,"title":["Temporal-Spatial Distribution of Hepatocyte Nuclear Factor-3\u03b2 in Developing Human Lung and Other Foregut Derivatives"],"prefix":"10.1177","volume":"46","author":[{"given":"Mildred T.","family":"Stahlman","sequence":"first","affiliation":[{"name":"Division of Neonatology, Departments of Pediatrics Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Gray","sequence":"additional","affiliation":[{"name":"Pathology Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Whitsett","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, Tennessee, and Division of Neonatology and Pulmonary Biology Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"bibr1-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90522-3"},{"key":"bibr2-002215549804600809","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1242\/dev.119.4.1301","volume":"119","author":"Ang SL","year":"1993","journal-title":"Development"},{"key":"bibr3-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1042\/bj2950227"},{"key":"bibr4-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.9.5671"},{"key":"bibr5-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.12.6531"},{"key":"bibr6-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1307"},{"key":"bibr7-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.14.8108"},{"key":"bibr8-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.11.2126"},{"key":"bibr9-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.12.6881"},{"key":"bibr10-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1177\/44.12.8985135"},{"key":"bibr11-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1177\/42.9.8064126"},{"key":"bibr12-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1177\/41.9.8354874"},{"key":"bibr13-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.1.60"},{"key":"bibr14-002215549804600809","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1242\/dev.118.1.47","volume":"118","author":"Sasaki H","year":"1993","journal-title":"Development"},{"key":"bibr15-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90176-7"},{"key":"bibr16-002215549804600809","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1016\/S0021-9258(17)31778-7","volume":"269","author":"Sawaya PL","year":"1994","journal-title":"J Biol Chem"},{"key":"bibr17-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.7.3860"},{"key":"bibr18-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199204000-00012"},{"key":"bibr19-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1177\/44.7.8675988"},{"key":"bibr20-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90523-1"},{"key":"bibr21-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1177\/44.2.8609367"},{"key":"bibr22-002215549804600809","doi-asserted-by":"publisher","DOI":"10.1177\/44.10.8813084"}],"container-title":["Journal of Histochemistry &amp; 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