{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:53:01Z","timestamp":1790621581657,"version":"4.1.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Learn Disabil"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Fifteen children ages 7 to 9 years who had persistent reading difficulties despite adequate instruction were provided with intensive tutorial interventions. The interventions targeted deficient phonological processing and decoding skills for 8 weeks (2 hours per day) followed by an 8-week, 1-hour-per-day intervention that focused on the development of reading fluency skills. Spatiotemporal brain activation profiles were obtained at baseline and after each 8-week intervention program using magnetoencephalography during the performance of an oral sight-word reading task. Changes in brain activity were found in the posterior part of the middle temporal gyrus (Brodmann's Area [BA] 21: increased degree of activity and reduced onset latency), the lateral occipitotemporal region (BA 19\/37: decreased onset latency of activation), and the premotor cortex (increased onset latency). Overall changes associated with the intervention were primarily normalizing, as indicated by (a) increased activity in a region that is typically involved in lexical\u2014semantic processing (BA 21) and (b) a shift in the relative timing of regional activity in temporal and frontal cortices to a pattern typically seen in unimpaired readers. These findings extend previous results in demonstrating significant changes in the spatiotemporal profile of activation associated with word reading in response to reading remediation.<\/jats:p>","DOI":"10.1177\/00222194070400010301","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T00:52:20Z","timestamp":1197593540000},"page":"37-48","source":"Crossref","is-referenced-by-count":45,"title":["Intensive Instruction Affects Brain Magnetic Activity Associated with Oral Word Reading in Children with Persistent Reading Disabilities"],"prefix":"10.1177","volume":"40","author":[{"given":"Panagiotis G.","family":"Simos","sequence":"first","affiliation":[{"name":"Department of Psychology at the University of Crete, Greece, .uoc.gr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center-Houston, Center for Academic and Reading Skills (CARS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Sarkari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery at the University of Texas Health Science Center-Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Billingsley-Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery at the University of Texas Health Science Center-Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Denton","sequence":"additional","affiliation":[{"name":"Department of Special Education at the University of Texas at Austin, Vaughn-Gross Center for Reading and Language Arts at the university"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Papanicolaou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Clinical Neurosciences and of the Magnetoencephalography Laboratory at the University of Texas Health Science Center-Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000068363.05974.64"},{"key":"atypb2","unstructured":"Berninger, V.W., Nagy, W.E., Carlisle, J., Thomson, J., Hoffer, D., Abbott, S., et al. 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