{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:40:25Z","timestamp":1777894825844,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T00:00:00Z","timestamp":1380153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) can lead to adverse effects such as gastrointestinal distress. The complexation of different groups of active substances with \u03b2-cyclodextrin (\u03b2-CD) has drawn considerable interest over recent years. The purpose of this study was to analyze the ketoprofen\/\u03b2-cyclodextrin (K\/\u03b2-CD) conjugate complex as well as to assess its anti-inflammatory effect after oral administration (doses of 30\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and 15\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    of body surface), compared with ketoprofen. The studies were done on two models of experimentally-induced acute inflammation in rats ( n\u2009=\u200948, 6\/group), by means of intraplantar administration of a 10% aqueous kaolin suspension and intraperitoneal administration of a 1% sodium thioglycolate solution. The dynamics of the acute inflammatory process and the anti-inflammatory effects were monitored using plethysmometric determinations after 3, 6, 9, 12, 24 and 48\u2009h (plantar inflammation), and the absorbance of the exudates (spectrophotometrically read) and nucleated cell counts after 24\u2009h (peritoneal inflammation). The coupling of ketoprofen with \u03b2-CD resulted in increased solubility (100% in 60\u2009min) of the newly-formed product, which further resulted in a higher bioavailability compared with ketoprofen (&lt;40% in 120\u2009min). In both models of experimentally-induced inflammation, the K\/\u03b2-CD complex had a higher anti-inflammatory activity than ketoprofen.\n                  <\/jats:p>","DOI":"10.1177\/0023677213503823","type":"journal-article","created":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T00:22:53Z","timestamp":1380241373000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparative assessment of effectiveness of ketoprofen and ketoprofen\/beta-cyclodextrin complex in two experimental models of inflammation in rats"],"prefix":"10.1177","volume":"48","author":[{"given":"Mariana","family":"Grecu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Agricultural Sciences and Veterinary Medicine, Lasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"N\u0103stas\u0103","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Agricultural Sciences and Veterinary Medicine, Lasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Ilie","sequence":"additional","affiliation":[{"name":"Department of Colloids, \u2018Ilie Murgulescu\u2019 Institute of Physical Chemistry, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Miron","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Department of Parasitology, University of Agricultural Sciences and Veterinary Medicine, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Mare\u015f","sequence":"additional","affiliation":[{"name":"Department of Public Health and Department of Microbiology, University of Agricultural Sciences and Veterinary Medicine, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"bibr1-0023677213503823","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.76.75"},{"key":"bibr2-0023677213503823","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.09.002"},{"key":"bibr3-0023677213503823","unstructured":"Bonagura JD and Twedt DC. 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