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To meet the requirements of intense caretaking and examination without stress, a 2-week socialisation and training programme was developed. Conventional cross-breed pigs ( n\u2009=\u200936) with high health status were trained for 15\u2009min\/day in a four-step training programme before kidney transplantation. The systematic training resulted in calm animals, which allowed for ultrasound examination, blood sampling and urine sampling without restraint. When a 2-methacryloyloxyethyl phosphorylcholine polymer-coated jugular catheter introduced via the auricular vein was used for post-operative blood sampling, clotting was avoided. To assess renal function, urinary output was observed and creatinine and cystatin C were measured; the latter was not found to be useful in recently transplanted pigs. The results presented contribute to the 3Rs (refine, reduce, replace).<\/jats:p>","DOI":"10.1177\/0023677219879169","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T01:33:42Z","timestamp":1571967222000},"page":"469-478","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Nursing and training of pigs used in renal transplantation studies"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-5023","authenticated-orcid":false,"given":"Anneli","family":"Ryd\u00e9n","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Manell","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Biglarnia","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Sk\u00e5ne University Hospital Malm\u00f6, Lund University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hedenqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Strandberg","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Sk\u00e5ne University Hospital Malm\u00f6, Lund University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-6712","authenticated-orcid":false,"given":"Kerstin","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6rel","family":"Nyman","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Jensen-Waern","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Swedish University of Agricultural Sciences, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"bibr1-0023677219879169","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"bibr2-0023677219879169","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60687-X"},{"key":"bibr3-0023677219879169","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03283.x"},{"key":"bibr4-0023677219879169","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.21015.x"},{"key":"bibr5-0023677219879169","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.47.4.358"},{"key":"bibr6-0023677219879169","unstructured":"Swindle MM and Smith A.\n                      Swine in the laboratory. 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