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It has previously been reported that NSG\u2122 mice are hyper-sensitive to doxorubicin due to the impairment of DNA damage repair mechanisms. As such, doxorubicin causes a wide spectrum of toxicities including cardiotoxicity, hepatotoxicity and intestinal toxicity in NSG\u2122 mice. Doxil is an alternative clinical formulation of doxorubicin, where doxorubicin is encapsulated within pegylated liposomes and displays improved toxicity profiles compared to conventional doxorubicin. Doxil was substituted for doxorubicin in our study to determine its toxicity profile in female NSG\u2122 mice. The mice that were treated with Doxil developed dose-dependent histopathological alterations associated with non-glandular gastritis, with non- Helicobacter spp. bacterial infiltrates, as well as oesophagitis. Of note, a study using a dose of 2 mg\/kg Doxil was terminated early due to significant weight loss while the use of Doxil at 1 mg\/kg allowed for repeated treatment of twice a week for a duration of three weeks. A dose optimised treatment regimen has now been established and can be applied to assess Doxil-related anti-tumour efficacy in a range of PDX-bearing NSG\u2122 mice.<\/jats:p>","DOI":"10.1177\/00236772211009338","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T02:01:29Z","timestamp":1618884089000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Observation of non-glandular gastritis associated with Doxil chemotherapy treatment in NSG\u2122 mice"],"prefix":"10.1177","volume":"55","author":[{"given":"Alison","family":"Cheong","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Cerberus Sciences, 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