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It is characterized by an inflammatory response of the denture-bearing mucosa, especially the palatal mucosa, and its clinical signs include chronic edema and erythema, and papillary hyperplasia. Despite having a multifactorial etiology, its main etiological agent is the infection by\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    . Given its high treatment failure rates, an in vivo model of denture stomatitis should be established to test alternative treatments. The aim of this study is to review the existing denture stomatitis models and to provide an overview of the main methodological differences between them. Over the last 40 years, different animal models were developed in order to study denture stomatitis etiopathogenesis and to assess novel therapies. Many approaches, including the use of antibiotics and immunosuppressors, have to be further investigated in order to establish which protocol is more appropriate and effective for the development of an animal model of denture stomatitis.\n                  <\/jats:p>","DOI":"10.1177\/00236772211069249","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T09:54:25Z","timestamp":1643018065000},"page":"331-343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Experimental animal models for denture stomatitis: A methodological review"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0777-5012","authenticated-orcid":false,"given":"Gustavo S","family":"Moraes","sequence":"first","affiliation":[{"name":"State University of Ponta Grossa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds","family":"Albach","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina YC","family":"Sugio","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio B","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-2667","authenticated-orcid":false,"given":"Karin H","family":"Neppelenbroek","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa M","family":"Urban","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12477"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1308\/205016817822230175"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245811"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2020-0865"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019741"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002349"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12961"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuab005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.019901"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2015.1025192"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701644140"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201720170238"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818422-6.00012-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-020-00370-x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800964-2.00010-0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811710-1.00008-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-285-4_1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.398-429.2001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016357109026330"},{"key":"e_1_3_3_21_2","first-page":"135","article-title":"Experimental palatal candidosis and saliva flow in monkeys","volume":"85","author":"Olsen I","year":"1977","unstructured":"Olsen I, Haanaes HR. 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