{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:45:03Z","timestamp":1777895103962,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Melatonin (ML) and dexmedetomidine (DM) are used separately as anesthetic premedication or as an anesthetic in humans and laboratory animals. In this study, we aimed to investigate the anesthetic properties of both drugs combined. The anesthetic effects of several combinations of ML (50 and 100\u2009mg\/kg) and DM (50 and 100\u2009\u03bcg\/kg) were evaluated in rats by observing behavioral manifestations and recording the duration and depth of anesthesia. Five anesthetic intervals were established according to the loss and recovery of reflexes. While each individual drug did not induce an appropriate anesthetic effect at the tested doses, ML50\u2009+\u2009DM100, ML100\u2009+\u2009DM50 and ML100\u2009+\u2009DM100 combinations resulted in surgical anesthesia intervals of 60 to 360\u2009min. Together, our results point that the use of ML allows to decrease the dose of DM, reducing the unwanted anesthetic effects of this \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -agonist.\n                  <\/jats:p>","DOI":"10.1177\/00236772231163211","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:43:20Z","timestamp":1716446600000},"page":"277-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining melatonin with dexmedetomidine improves anesthesia in rats"],"prefix":"10.1177","volume":"58","author":[{"given":"Joaqu\u00edn","family":"Cogo Pagella","sequence":"first","affiliation":[{"name":"Institute of Basic and Experimental Sciences (IBES, SeCyT-UM), University of Mor\u00f3n, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda F","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Institute of Basic and Experimental Sciences (IBES, SeCyT-UM), University of Mor\u00f3n, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Frisina","sequence":"additional","affiliation":[{"name":"Institute of Basic and Experimental Sciences (IBES, SeCyT-UM), University of Mor\u00f3n, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-758X","authenticated-orcid":false,"given":"Claudio","family":"O Cervino","sequence":"additional","affiliation":[{"name":"Institute of Basic and Experimental Sciences (IBES, SeCyT-UM), University of Mor\u00f3n, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"bibr1-00236772231163211","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00384.x"},{"key":"bibr2-00236772231163211","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200011000-00030"},{"key":"bibr3-00236772231163211","first-page":"75","volume":"76","author":"Bello N","year":"2018","journal-title":"Rev Argent Anestesiol"},{"key":"bibr4-00236772231163211","first-page":"1","volume":"76","author":"Cogo Pagella J","year":"2022","journal-title":"Rev Argent Anestesiol"},{"key":"bibr5-00236772231163211","doi-asserted-by":"publisher","DOI":"10.1258\/002367793781082377"},{"key":"bibr6-00236772231163211","doi-asserted-by":"publisher","DOI":"10.1258\/002367707781282767"}],"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00236772231163211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00236772231163211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00236772231163211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:42:44Z","timestamp":1777621364000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00236772231163211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/00236772231163211"],"URL":"https:\/\/doi.org\/10.1177\/00236772231163211","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]}}}