{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:33:44Z","timestamp":1784864024736,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    An alternative in an attempt to minimize the effects triggered by intravenous (IV) bolus administration of \u03b1-2 adrenergic receptor agonists are continuous rate infusions (CRI). The requirement for sedation protocols in sheep for procedures to be performed without physical restraint and with reduced adverse effects, commonly observed with bolus use, justifies the study of CRI. The aim of study was to compare the cardiopulmonary and sedative effects of IV bolus injection and CRI of dexmedetomidine (DEX) in sheep. Six adult male sheep (38.3\u2009\u00b1\u20097.6\u2009kg) received DEX as a bolus (5\u2009\u00b5g\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , DEX\n                    <jats:sub>bolus<\/jats:sub>\n                    treatment) or CRI (5\u2009\u00b5g\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    h\n                    <jats:sup>\u22121<\/jats:sup>\n                    for 1\u2009h, DEX\n                    <jats:sub>CRI<\/jats:sub>\n                    treatment). We recorded heartrate (HR), respiratory rate, systemic arterial blood pressure, pulse oximetry, hemodynamic parameters, blood gases and sedation scores over 120\u2009min. HR was significantly lower in DEX\n                    <jats:sub>bolus<\/jats:sub>\n                    at 5 and 15\u2009min than in DEX\n                    <jats:sub>CRI<\/jats:sub>\n                    , with HR reduction observed for 30\u2009min in DEX\n                    <jats:sub>bolus<\/jats:sub>\n                    . Hypoxemia was noted in DEX\n                    <jats:sub>bolus<\/jats:sub>\n                    at 10 and 30\u2009min. Pulmonary vascular resistance index increased at 5\u2009min, and cardiac index (CI) decreased at all timepoints compared with baseline in DEX\n                    <jats:sub>bolus<\/jats:sub>\n                    . In DEX\n                    <jats:sub>CRI<\/jats:sub>\n                    , CI decreased only at 45\u2009min. Sedation scores were higher in DEX\n                    <jats:sub>bolus<\/jats:sub>\n                    at 15 and 30\u2009min. DEX CRI administration resulted in fewer cardiorespiratory and hemodynamic changes compared with bolus injection and lower sedation scores (&lt;4\/10), which would not allow animal handling without a reaction. The load dose used in CRI was a limitation to constant infusion.\n                  <\/jats:p>","DOI":"10.1177\/00236772241277891","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T01:51:36Z","timestamp":1732153896000},"page":"242-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiorespiratory, hemodynamic, and sedative effects of dexmedetomidine in sheep"],"prefix":"10.1177","volume":"59","author":[{"given":"Janainne Hilbig","family":"Gomes","sequence":"first","affiliation":[{"name":"Escola de Veterin\u00e1ria e Zootecnia, Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-392X","authenticated-orcid":false,"given":"Isabela Plazza","family":"Bittar","sequence":"additional","affiliation":[{"name":"Escola de Veterin\u00e1ria e Zootecnia, Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauane Sousa de","family":"Moura","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Gin\u00fa","family":"Prado","sequence":"additional","affiliation":[{"name":"Escola de Veterin\u00e1ria e Zootecnia, Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7971-7789","authenticated-orcid":false,"given":"Leandro Guimar\u00e3es","family":"Franco","sequence":"additional","affiliation":[{"name":"Escola de Veterin\u00e1ria e Zootecnia, Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2001.00354.x"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.159.19.624"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12339"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2006.05.001"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.11.015"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00663.x"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.1496"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12220"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2019.04.013"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2006.00701.x"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12139"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054406801"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0023677217714013"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(03)73966-6"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06959-8.00040-6"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2003.00492.x"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00233.x"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00061-7"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1997.tb04796.x"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1997.00097.x"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00243.x"},{"issue":"3","key":"e_1_3_6_23_2","first-page":"267","article-title":"Alpha 2 adrenoceptor agonist-dexmedetomidine role in anaesthesia and intensive care: a clinical review","volume":"25","author":"Murthy TV","year":"2009","unstructured":"Murthy TV, Singh R. Alpha 2 adrenoceptor agonist-dexmedetomidine role in anaesthesia and intensive care: a clinical review. J Anaesthesiol Clin Pharmacol 2009; 25(3): 267\u2013272.","journal-title":"J Anaesthesiol Clin Pharmacol"}],"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00236772241277891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00236772241277891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00236772241277891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:44:13Z","timestamp":1777621453000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00236772241277891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/00236772241277891"],"URL":"https:\/\/doi.org\/10.1177\/00236772241277891","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]}}}