{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:46:11Z","timestamp":1777895171863,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    For over 40 years, ivermectin has served as an effective anti-parasitic drug used in human and veterinary medicine. In laboratory animal facilities it is used prophylactically or therapeutically to maintain the health status of the colony or experimentally in studies. Although ivermectin is generally safe to use, there are reports of neurotoxicity associated with ivermectin crossing the blood\u2013brain barrier due to overdosing or blood\u2013brain barrier dysfunction. In mice, P-glycoprotein maintains the blood\u2013brain barrier and mice with a mutation in the P-glycoprotein encoding gene\n                    <jats:italic toggle=\"yes\">mdr1a<\/jats:italic>\n                    are 50\u2013100 times more sensitive to ivermectin. Signs of neurotoxicity include ataxia, bradypnea, recumbency, tremor, and death. We report neurotoxicity after ivermectin administration was used for the purpose of eradicating the murine-specific intestinal nematode\n                    <jats:italic toggle=\"yes\">Heligmosomoides polygyrus<\/jats:italic>\n                    in C57BL\/6NTac and C57BL\/6NCrl mice. The mice were dewormed by subcutaneous administration of 10 or 20\u2009mg\/kg ivermectin to eradicate all stages of\n                    <jats:italic toggle=\"yes\">Heligmosomoides polygyrus<\/jats:italic>\n                    . At 24\u201348h after deworming, 5% (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20094) of the mice presented with tremor, ataxia, and\/or head tilt. The affected mice were euthanised and gross pathological findings were found in one of the four mice (left-sided hydronephrosis). We assume that the observed neurological effects were due to defects in the blood\u2013brain barrier, overdosing or individual sensitivity. This report provides a reason for caution when deworming laboratory mice subcutaneously with ivermectin at doses of 10\u2009mg\/kg or higher.\n                  <\/jats:p>","DOI":"10.1177\/00236772241286214","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:52:48Z","timestamp":1735019568000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: C57BL\/6NTac and C57BL\/6NCrl mice displaying neurological signs after deworming with ivermectin"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4727-1391","authenticated-orcid":false,"given":"M.","family":"Eriksson","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Microbiology, Swedish Veterinary Agency, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nyl\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.87.13"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30289-0"},{"key":"e_1_3_4_4_2","first-page":"100942","article-title":"Effectiveness of one and two doses of ivermectin mass drug administration in reducing the prevalence and intensity of soil-transmitted helminth (STH) infections in Western Province, Solomon Islands: a cluster-randomised, before-after analysis","volume":"42","author":"Le B","year":"2023","unstructured":"Le B, Clarke NE, Hii SF, et\u00a0al. Effectiveness of one and two doses of ivermectin mass drug administration in reducing the prevalence and intensity of soil-transmitted helminth (STH) infections in Western Province, Solomon Islands: a cluster-randomised, before-after analysis. Lancet Reg Health West Pac 2023; 42: 100942.","journal-title":"Lancet Reg Health West Pac"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0450.2002.00576.x"},{"key":"e_1_3_4_6_2","first-page":"633","article-title":"Treatment and eradication of murine fur mites: III. Treatment of a large mouse colony with ivermectin-compounded feed","volume":"49","author":"Ricart Arbona RJ","year":"2010","unstructured":"Ricart Arbona RJ, Lipman NS, Wolf FR. Treatment and eradication of murine fur mites: III. Treatment of a large mouse colony with ivermectin-compounded feed. 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