{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:46:06Z","timestamp":1777895166893,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"FELASA","award":["44"],"award-info":[{"award-number":["44"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Good education and training for scientists undertaking animal experiments is important for providing understanding of key issues in experimental design (ED) and for alleviating continuing concerns about the conduct of animal and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    research studies. We present here outputs from the FELASA Experimental Design Working Group, set up to consider the current provision of ED teaching and how it might be improved and harmonised across the laboratory animal science community. It is hoped that these outputs will provide practical help to ED teachers who wish to enhance the effectiveness of their teaching; they include\n                  <\/jats:p>\n                  <jats:p>\u2022\u2003A list of learning outcomes (LOs) that should be achieved by learners, principally aimed at early career researchers;<\/jats:p>\n                  <jats:p>\u2022\u2003An example of an (adaptable) template of how these LOs could be addressed in 16\u2009h (12\u2009h tuition plus breaks), ideally as a 2-day workshop. If circumstances make 12\u2009h tuition impossible to achieve, key LOs for a shorter course are identified;<\/jats:p>\n                  <jats:p>\u2022\u2003Guidance and recommendations for running ED courses, including some ideas for achieving effective learning, the ideal skill set for tutors, some teaching scenarios, and the amount of statistics to have in a basic experimental design course;<\/jats:p>\n                  <jats:p>\u2022\u2003A glossary of relevant terms (in supplemental material);<\/jats:p>\n                  <jats:p>\u2022\u2003A description of how the 2-day course format ran on two trial occasions, with results of informal assessment of participants as well as their feedback, both immediate and a year afterwards, indicating it was effective;<\/jats:p>\n                  <jats:p>\u2022\u2003A programme for a potential 2-day, training-the-trainers style, workshop, describing its key elements and the results of trialling this with a range of ED tutors.<\/jats:p>","DOI":"10.1177\/00236772241295308","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:39:17Z","timestamp":1750819157000},"page":"614-629","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Teaching experimental design: outputs from the FELASA Working Group"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-2783","authenticated-orcid":false,"given":"Derek","family":"Fry","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Manchester, Oxford Road, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Berdoy","sequence":"additional","affiliation":[{"name":"Biomedical Services, Oxford University, Mansfield Road, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Forni","sequence":"additional","affiliation":[{"name":"University of Bologna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Oscar S.","family":"Sorzano","sequence":"additional","affiliation":[{"name":"National Center of Biotechnology (CSIC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Steckler","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica NV, Beerse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4015-0532","authenticated-orcid":false,"given":"Nuno H.","family":"Franco","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/533452a"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/483531a"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3439-c1"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007824"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjos-2018-000016"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2019.73.298-302"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005282"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.36866\/pn.118.14"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119290903700107"},{"key":"e_1_3_7_11_2","unstructured":"Hudson-Shore M Millar K. VetBioNet Training School in Experimental Design and Statistical Analysis of Bioscience and Biomedical Research (Del. 5.4) https:\/\/www.vetbionet.eu\/wp-content\/uploads\/2020\/06\/D5.4_VetBioNet-3Rs-Training-Event-Professional-Training-School-in-Experimental-Design-and-Statistical-Analysis.pdf (2019 accessed 25 January 2025)."},{"key":"e_1_3_7_12_2","volume-title":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes","author":"European Parliament and Council of the European Union","year":"2010","unstructured":"European Parliament and Council of the European Union. Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Strasbourg: Council of Europe, 2010."},{"key":"e_1_3_7_13_2","unstructured":"Holloway M Florean O Busquet F et al. Three Rs Education and Training Courses and Resources. European Commission Joint Research Centre (JRC) http:\/\/data.europa.eu\/89h\/d0569abb-b5ab-4b9e-9e16-d70cea7a89f9 (2019 accessed 25 January 2025)."},{"key":"e_1_3_7_14_2","volume-title":"National Competent Authorities for the implementation of Directive 2010\/63\/EU on the protection of animals used for scientific purposes \u2013 a working document on the development of a common education and training framework to fulfil the requirements under the Directive","author":"European Commission","year":"2014","unstructured":"European Commission. National Competent Authorities for the implementation of Directive 2010\/63\/EU on the protection of animals used for scientific purposes \u2013 a working document on the development of a common education and training framework to fulfil the requirements under the Directive. Brussels: European Commission, 2014."},{"key":"e_1_3_7_15_2","first-page":"53","article-title":"Round table: train the trainers on experimental design. Abstracts of 14th FELASA congress 2019","volume":"53","author":"Mocho J-P.","year":"2019","unstructured":"Mocho J-P. Round table: train the trainers on experimental design. Abstracts of 14th FELASA congress 2019. Lab Anim 2019; 53: 53.","journal-title":"Lab Anim"},{"key":"e_1_3_7_16_2","first-page":"53","article-title":"Making experimental design education more effective. Abstracts of 14th FELASA congress 2019","volume":"53","author":"Bate S","year":"2019","unstructured":"Bate S, Fry D. Making experimental design education more effective. Abstracts of 14th FELASA congress 2019. Lab Anim 2019; 53: 53.","journal-title":"Lab Anim"},{"key":"e_1_3_7_17_2","first-page":"114","article-title":"Communicating good experimental design: an interactive workshop in two parts. Abstracts of 15th FELASA congress 2022","volume":"56","author":"Fry D","year":"2022","unstructured":"Fry D, Steckler T, Sorzano COS, et al. Communicating good experimental design: an interactive workshop in two parts. Abstracts of 15th FELASA congress 2022. Lab Anim 2022; 56: 114.","journal-title":"Lab Anim"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilu031"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/00236772221150299"},{"key":"e_1_3_7_20_2","volume-title":"The design of animal experiments: reducing the use of animals in research through better experimental design","author":"Festing M","year":"2016","unstructured":"Festing M, Overend P, Cortina Borja M, et al. The design of animal experiments: reducing the use of animals in research through better experimental design. 2nd ed. London: Sage Publications, 2016.","edition":"2"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0023677217724823"},{"key":"e_1_3_7_22_2","doi-asserted-by":"crossref","unstructured":"Sorzano COS. Statistical experiment design for animal research. OSF Preprints https:\/\/doi.org\/10.31219\/osf.io\/e9s25 (2023 accessed 25 January 2025).","DOI":"10.31219\/osf.io\/e9s25"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0023677216642398"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003779"},{"key":"e_1_3_7_25_2","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert N","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 2020; 18: e3000410.","journal-title":"PLoS Biol"},{"key":"e_1_3_7_26_2","unstructured":"Education and Training Platform for Laboratory Animal Science https:\/\/www.etplas.eu (n.d. accessed 7 December 2023)."}],"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00236772241295308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00236772241295308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00236772241295308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:44:22Z","timestamp":1777621462000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00236772241295308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00236772241295308"],"URL":"https:\/\/doi.org\/10.1177\/00236772241295308","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]}}}