{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:46:00Z","timestamp":1777895160157,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>The immunogenicity of rabies vaccines is commonly measured by serological testing, which includes measuring rabies virus-neutralising antibody titre levels in the serum. Apart from humoral immunity, cellular immunity measurements are also helpful in assessing the immunogenicity and efficacy of rabies vaccinations. Recently, there has been an increased emphasis on cellular immunity measurements against rabies in humans and animals. This review aimed to systematically analyse the literature on the composition of cellular immune responses against rabies vaccination in laboratory dogs. A literature survey was conducted to collect suitable articles by searching the research databases PubMed, Web of Science and Scopus. Subsequently, a two-person screening was conducted to identify suitable articles based on predetermined inclusion and exclusion criteria. Data extraction was performed by two authors independently. A total of 1396 studies were identified from the initial search. Following the screening, six studies were selected for final review. Different methods of detecting immune parameters from peripheral blood mononuclear cells were identified from the studies. Reports have demonstrated positive outcomes of the use of adjuvants for cellular immunity development. Even though the lack of specific immunological techniques and the specific reagents have negatively affected these types of cellular immunity measurements, it was evident that combining both humoral and cellular immune parameters against the rabies antigen would provide a clearer picture of the level of responsiveness in animals towards vaccinations and the protection against the disease. The protocol for this review was published in the International Prospective Register of Systematic Review (CRD42022380023).<\/jats:p>","DOI":"10.1177\/00236772241300782","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:11:08Z","timestamp":1738041068000},"page":"342-355","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cellular immune response against rabies vaccination in laboratory-bred dogs: A systematised review"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-3230","authenticated-orcid":false,"given":"Hasanthi","family":"Rathnadiwakara","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachini","family":"Amarasekara","sequence":"additional","affiliation":[{"name":"Department of Zoology and Environment Sciences, Faculty of Science, University of Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Cliquet","sequence":"additional","affiliation":[{"name":"EU\/WOAH\/WHO Reference Laboratory for Rabies, OMCL for Rabies Vaccines, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Thibault","sequence":"additional","affiliation":[{"name":"JC &amp; P Life Science Partner, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan N","family":"Jalaldeen","sequence":"additional","affiliation":[{"name":"Optical Science Centre, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangala","family":"Gunatilake","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization. Rabies https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/rabies (accessed 11 February 2024)."},{"key":"e_1_3_2_3_2","unstructured":"World Health Organization. United against rabies forum: zero by 30: one health in action https:\/\/www.who.int\/publications\/i\/item\/WHO-UCN-NTD-VVE-2021.1 (2021 accessed 17 March 2024)."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2017.00009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006490"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11050961"},{"key":"e_1_3_2_7_2","unstructured":"World Health Organization. WHO expert consultation on rabies: WHO TRS N\u00b01012 https:\/\/www.who.int\/publications\/i\/item\/WHO-TRS-1012 (2018 accessed 17 March 2024)."},{"key":"e_1_3_2_8_2","unstructured":"SAGE. Proposed revision of the policy on rabies vaccines and rabies immunoglobulins https:\/\/www.nitag-resource.org\/sites\/default\/files\/0cd83c26cce042fc02a514aa7c31e9616f281f46_1.pdf (2017 accessed 10 March 2024)."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.1.334"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7030110"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3152"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2015.4.1.68"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2017.06.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2019.109986"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.564497"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5904"},{"key":"e_1_3_2_17_2","first-page":"153","article-title":"Duration of immunity after rabies vaccination in dogs: the Rabies Challenge Fund research study","volume":"84","author":"Dodds WJ","year":"2020","unstructured":"Dodds WJ, Larson LJ, Christine KL, et\u00a0al. 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